Lymphocytes have their membrane potential changed during transition from the resting to the active state. On these grounds, we investigated the response of human peripheral lymphocytes to a depolarizing high-potassium (102.7 mM) medium, by assaying cellular incorporation of labeled thymidine and interferon (IFN) release in the culture medium. The greatest effect is evident 3-4 days after preincubation for 120 min in high K+ medium. A temporal correlation has been observed between rate of DNA synthesis and IFN production. The IFN activity is shown to be gamma-type

Viti, A., Pacini, A., Pessina, G.p., Muscettola, M., Ricci, L., Fanetti, G. (1987). DNA synthesis and interferon release by human peripheral lymphocytes exposed to high potassium medium. . PubMed PMID:2433697. PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 184(2), 133-137.

DNA synthesis and interferon release by human peripheral lymphocytes exposed to high potassium medium. . PubMed PMID:2433697.

Pacini A;Pessina GP;Muscettola M;Ricci L;FANETTI, GIULIA
1987-01-01

Abstract

Lymphocytes have their membrane potential changed during transition from the resting to the active state. On these grounds, we investigated the response of human peripheral lymphocytes to a depolarizing high-potassium (102.7 mM) medium, by assaying cellular incorporation of labeled thymidine and interferon (IFN) release in the culture medium. The greatest effect is evident 3-4 days after preincubation for 120 min in high K+ medium. A temporal correlation has been observed between rate of DNA synthesis and IFN production. The IFN activity is shown to be gamma-type
Viti, A., Pacini, A., Pessina, G.p., Muscettola, M., Ricci, L., Fanetti, G. (1987). DNA synthesis and interferon release by human peripheral lymphocytes exposed to high potassium medium. . PubMed PMID:2433697. PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 184(2), 133-137.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/28975
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