The use of the bicyclo[3.3.1]nonane derived keto urethane (3) in a general synthesis of open chain and modified heterocyclic analogues of huperzine A was investigated and resulted in the preparation of the dimethylcarbamoyloxy analogue (27). Thiazole annulation by the Gewald procedure gave only the undesired regioisomer (36). © 1994.
Kozikowski, A.P., Campiani, G., Tuckmantel, W. (1994). An approach to open chain and modified heterocyclic analogues of the acetylcholinesterase inhibitor, huperzine A, through a bicyclo[3.3.1]nonane intermediate. HETEROCYCLES, 39(1), 101-116 [10.3987/com-93-s(b)3].
An approach to open chain and modified heterocyclic analogues of the acetylcholinesterase inhibitor, huperzine A, through a bicyclo[3.3.1]nonane intermediate
CAMPIANI G.;
1994-01-01
Abstract
The use of the bicyclo[3.3.1]nonane derived keto urethane (3) in a general synthesis of open chain and modified heterocyclic analogues of huperzine A was investigated and resulted in the preparation of the dimethylcarbamoyloxy analogue (27). Thiazole annulation by the Gewald procedure gave only the undesired regioisomer (36). © 1994.
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https://hdl.handle.net/11365/28315
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