An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.
Castagnolo, D., Botta, M. (2010). Iron-catalyzed cross-coupling between 1-Bromoalkynes and grignard-derived organocuprate reagents. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 1, 3224-3228 [10.1002/ejoc.201000393].
Iron-catalyzed cross-coupling between 1-Bromoalkynes and grignard-derived organocuprate reagents
CASTAGNOLO, DANIELE;BOTTA, MAURIZIO
2010-01-01
Abstract
An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.
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https://hdl.handle.net/11365/2756
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