An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.
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|Titolo:||Iron-catalyzed cross-coupling between 1-Bromoalkynes and grignard-derived organocuprate reagents|
|Rivista:||EUROPEAN JOURNAL OF ORGANIC CHEMISTRY|
|Citazione:||Castagnolo, D., & Botta, M. (2010). Iron-catalyzed cross-coupling between 1-Bromoalkynes and grignard-derived organocuprate reagents. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 1, 3224-3228.|
|Appare nelle tipologie:||1.1 Articolo in rivista|