An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.
Castagnolo, D., Botta, M. (2010). Iron-catalyzed cross-coupling between 1-Bromoalkynes and grignard-derived organocuprate reagents. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2010(17), 3224-3228 [10.1002/ejoc.201000393].
Iron-catalyzed cross-coupling between 1-Bromoalkynes and grignard-derived organocuprate reagents
Castagnolo, Daniele;Botta, Maurizio
2010-01-01
Abstract
An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.File | Dimensione | Formato | |
---|---|---|---|
3224_ftp.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
211.06 kB
Formato
Adobe PDF
|
211.06 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/2756
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo