Recombinant human interferon-gamma (HuIFN-gamma) injected into rabbits disappeared from the circulation more rapidly than natural IFN-gamma. The latter displayed an initial decay curve more rapid than that for natural HuIFN-alpha although 4 h after injection plasma levels were similar. This result suggests that IFN-gamma has pharmacokinetic properties different to those of IFN-alpha which may be explained by considerable and simultaneous hepatic and renal catabolism. Surprisingly, the hepatic uptake of recombinant (unglycosylated) IFN-gamma was more marked than uptake of natural IFN-gamma. Moreover, both IFN-gamma preparations were cleared by the isolated and perfused kidney and once again the recombinant IFN disappeared more rapidly. This result does not conform with the suggestion that IFN-gamma exists as a tetramer which would not be filtered by the glomerulus, but is consistent with the pharmacokinetic behaviour shown in vivo.

Bocci, V., Pacini, A., Pessina, G.p., Ricci, L., Muscettola, M., Lunghetti, G. (1985). Catabolic sites of human interferon-gamma. JOURNAL OF GENERAL VIROLOGY, 66(4), 887-891 [10.1099/0022-1317-66-4-887].

Catabolic sites of human interferon-gamma

Pacini A;Pessina GP;Ricci L;Muscettola M;
1985-01-01

Abstract

Recombinant human interferon-gamma (HuIFN-gamma) injected into rabbits disappeared from the circulation more rapidly than natural IFN-gamma. The latter displayed an initial decay curve more rapid than that for natural HuIFN-alpha although 4 h after injection plasma levels were similar. This result suggests that IFN-gamma has pharmacokinetic properties different to those of IFN-alpha which may be explained by considerable and simultaneous hepatic and renal catabolism. Surprisingly, the hepatic uptake of recombinant (unglycosylated) IFN-gamma was more marked than uptake of natural IFN-gamma. Moreover, both IFN-gamma preparations were cleared by the isolated and perfused kidney and once again the recombinant IFN disappeared more rapidly. This result does not conform with the suggestion that IFN-gamma exists as a tetramer which would not be filtered by the glomerulus, but is consistent with the pharmacokinetic behaviour shown in vivo.
Bocci, V., Pacini, A., Pessina, G.p., Ricci, L., Muscettola, M., Lunghetti, G. (1985). Catabolic sites of human interferon-gamma. JOURNAL OF GENERAL VIROLOGY, 66(4), 887-891 [10.1099/0022-1317-66-4-887].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/27486
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