A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.

Botta, M., S., A., D., C., G., F., P., P., & E., B. (2007). ‘Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J’. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17(6), 1579-1583.

‘Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J’

BOTTA, MAURIZIO;
2007

Abstract

A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
Botta, M., S., A., D., C., G., F., P., P., & E., B. (2007). ‘Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J’. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17(6), 1579-1583.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/2679
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