A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
Botta, M., Armaroli, S., Castagnolo, D., Fontana, G., Pera, P., Bombardelli, E. (2007). Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17(6), 1579-1583 [10.1016/j.bmcl.2006.12.101].
Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J
Botta, Maurizio;
2007-01-01
Abstract
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
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https://hdl.handle.net/11365/2679
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