The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished. The activity of these agents against positive strand (rubella virus and sindbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus.

Botta, M., Occhionero, F., Nicoletti, R., Mastromarino, P., Conti, C., Magrini, M., et al. (1999). Synthesis and biological evaluation of 2-methoxy- and 2-Methylthio-6-[(2′-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity. BIOORGANIC & MEDICINAL CHEMISTRY, 7(9), 1925-1931.

Synthesis and biological evaluation of 2-methoxy- and 2-Methylthio-6-[(2′-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity

BOTTA, MAURIZIO;
1999

Abstract

The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished. The activity of these agents against positive strand (rubella virus and sindbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/26788
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