Haptoglobin (Hp) is an acute phase protein, binding free hemoglobin and thus preventing catalysis of reactive oxygen species. The Hp encoding gene is polymorphic and three major subtypes, Hp1-1, Hp2-1 and Hp2-2 are the product of two genes HP1 and HP2. Hp2-2 phenotype is associated with increased prevalence of various systemic diseases, including autoimmune disorders. Moreover, Hp2-2 phenotype induces shift from Th1 to Th2 response and increases fibrotic processes. Systemic sclerosis (SSc) is a connective tissue disorder characterised by interstitial and perivascular fibrosis, due to different factors, including genetic, environmental, immunological and microchimeric factors. It has been reported that SSc is associated with Th2-type immune response and that Th1-type enhancement correlates with the improvement in SSc skin fibrosis.We examined 28 SSc outpatients (6 males, 22 females, mean age 51±6.3 years), diagnosed according to ARA criteria, and 27 control subjects (5 males, 23 females, mean age 49±7.1 years) to verify the Hp phenotype distribution. Our data support the hypothesis that SSc is a Th2-driven disorder and suggest that Hp 1-1 phenotype, less prevalent in patients respect to controls, is protective toward the disease. In fact, Hp 1-1 phenotype is biologically the most effective in suppressing immunomediated inflammatory responses associated with free hemoglobin.
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|Titolo:||Haptoglobin Phenotypes in Systemic Sclerosis|
|Citazione:||Giordano, N.G., Guerranti, R., Bertocci, E., Papakostas, P., Rollo, F., Figura, N., et al. (2008). Haptoglobin Phenotypes in Systemic Sclerosis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 26(6), 1162-1162.|
|Appare nelle tipologie:||1.1 Articolo in rivista|