Proteomic approach is an effective method to study changes in human plasma proteome. Coagulopathies are commonly encountered in victims of viper envenomation which were treated with an administration of immunoglobulin. Unfortunately, this treatment shows significant risk to the patient due to an anaphylactic reaction. Since Echis carinatus Venom (EV) toxins mainly acts both directly and indirectly on fibrinogen, we planned to establish a suitable analysis of its beta (FIBB) e gamma (FIBG) chains. This study will help us to understand the mechanism of envenomation and to find alternative treatments other than the common treatment with the administration of IgG.
Cortelazzo, A., Guerranti, R., Bini, L., HOPE ONYEKWERE, N., Muzzi, C., Leoncini, R., et al. (2010). Effects of snake venom proteases on human fibrinogen chains. BLOOD TRANSFUSION, 8(suppl 3), s120-s125 [10.2450/2010.019S].
Effects of snake venom proteases on human fibrinogen chains
CORTELAZZO, ALESSIO;GUERRANTI, ROBERTO;BINI, LUCA;MUZZI, CHIARA;LEONCINI, ROBERTO;PAGANI, ROBERTO
2010-01-01
Abstract
Proteomic approach is an effective method to study changes in human plasma proteome. Coagulopathies are commonly encountered in victims of viper envenomation which were treated with an administration of immunoglobulin. Unfortunately, this treatment shows significant risk to the patient due to an anaphylactic reaction. Since Echis carinatus Venom (EV) toxins mainly acts both directly and indirectly on fibrinogen, we planned to establish a suitable analysis of its beta (FIBB) e gamma (FIBG) chains. This study will help us to understand the mechanism of envenomation and to find alternative treatments other than the common treatment with the administration of IgG.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/24204
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