The aim of the present study was to demonstrate the mitogenic and differentiating properties of platelet-rich plasma releasates (PRPr) on human chondrocytes in mono- and three-dimensional cultures. In order to assess if PRPr supplementation could maintain the chondrocyte phenotype or at least inhibit the cell de-differentiation even after several days in culture, we performed a proteomic study on several cell cultures independently grown, for different periods of time, in culture medium with FCS, human serum (HS), and releasates obtained from PRP and platelet-poor plasma (PPP). We found that PRP treatment actually induced in chondrocytes the expression of proteins (some of which novel) involved in differentiation.
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|Titolo:||Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes|
|Citazione:||Spreafico, A., Chellini, F., Frediani, B., Bernardini, G., Niccolini, S., Serchi, T., et al. (2009). Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes. JOURNAL OF CELLULAR BIOCHEMISTRY, 108(5), 1153-1165.|
|Appare nelle tipologie:||1.1 Articolo in rivista|