A small library of 2,6-disubstituted- and 2,5,6-trisubstituted-4(3H)-pyrimidinones has been synthesized by solid-phase synthesis starting from a modified Merrifield resin. The new pyrimidinones have been tested in vitro for their ability to inhibit HIV-1 RT in comparison with nevirapine. Interestingly, some of them showed moderate activity against recombinant RTs carrying mutations conferring resistance to TIBO/nevirapine. The possible mode of binding between Y188L mutant of RT and the new compounds has been studied through a molecular modeling approach.
Botta, M., Corelli, F., Maga, G., Manetti, F., Renzulli, M., Spadari, S. (2001). Research on anti-HIV-1 agents. Part 2. Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase. TETRAHEDRON, 57(39), 8357-8367 [10.1016/S0040-4020(01)00815-8].
Research on anti-HIV-1 agents. Part 2. Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase
Botta, Maurizio;Corelli, Federico;Manetti, Fabrizio;
2001-01-01
Abstract
A small library of 2,6-disubstituted- and 2,5,6-trisubstituted-4(3H)-pyrimidinones has been synthesized by solid-phase synthesis starting from a modified Merrifield resin. The new pyrimidinones have been tested in vitro for their ability to inhibit HIV-1 RT in comparison with nevirapine. Interestingly, some of them showed moderate activity against recombinant RTs carrying mutations conferring resistance to TIBO/nevirapine. The possible mode of binding between Y188L mutant of RT and the new compounds has been studied through a molecular modeling approach.
| File | Dimensione | Formato | |
|---|---|---|---|
|
2001TetrahedronHIVPyrimidinonesII.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
305.67 kB
Formato
Adobe PDF
|
305.67 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/20979
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo