Objective. Inflammation/infection is the most frequent conditions leading to preterm delivery (PTD). A few studies have assessed the clinical efficacy of long-term tocolysis with ritodrine hydrochloride. In this study, the relationship among inflammatory/infective risk factors of PTD, the response to long-term tocolysis, and timing of delivery were evaluated in women with preterm labor. Methods. On the basis of different responses to long-term tocolysis, defined as ≥ 7 days tocolysis, the cohort were classified as: (i) patients delivering at term (Group A) and (ii) patients delivering preterm (group B). Group B was subclassified as: (i) delivery before 48h (group B1); (ii) delivery between 48h and 7 days (Group B2), and (iii) delivery after 7 days (Group B3). Group B is divided in early preterm ( < 32 weeks) (Group B early) and late PTD (32-36 weeks) (Group B late). Results. Group A delivered at term and Group B preterm. Group B showed significantly higher (p < 0.0001) rate of CRP, bacterial vaginosis, and chorioamnionitis at placental histological examination than Group A. The same parameters were statistically higher (p < 0.0001) in group B1 than in B3. CRP, chorioamnionitis at placental histological examination was statistically higher (p < 0.0001) in Group B early than in Group B late. Conclusions. This retrospective study suggested that in women affected by preterm labor, the long-term tocolysis with intravenous ritodrine is able to prolong gestation beyond 7 days, in absence of inflammatory/infective risk factors of PTD. © 2011 Informa UK, Ltd.

Torricelli, M., Voltolini, C., Conti, N., De Bonis, M., Biliotti, G., Picciolini, E., et al. (2011). Inflammatory and infectious risk factors are associated with the response to tocolysis in patients with preterm labor. THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 24(1), 43-46 [10.3109/14767058.2010.482614].

Inflammatory and infectious risk factors are associated with the response to tocolysis in patients with preterm labor

Torricelli, M.;Voltolini, C.;Conti, N.;De Bonis, M.;Biliotti, G.;Picciolini, E.;Petraglia, F.
2011-01-01

Abstract

Objective. Inflammation/infection is the most frequent conditions leading to preterm delivery (PTD). A few studies have assessed the clinical efficacy of long-term tocolysis with ritodrine hydrochloride. In this study, the relationship among inflammatory/infective risk factors of PTD, the response to long-term tocolysis, and timing of delivery were evaluated in women with preterm labor. Methods. On the basis of different responses to long-term tocolysis, defined as ≥ 7 days tocolysis, the cohort were classified as: (i) patients delivering at term (Group A) and (ii) patients delivering preterm (group B). Group B was subclassified as: (i) delivery before 48h (group B1); (ii) delivery between 48h and 7 days (Group B2), and (iii) delivery after 7 days (Group B3). Group B is divided in early preterm ( < 32 weeks) (Group B early) and late PTD (32-36 weeks) (Group B late). Results. Group A delivered at term and Group B preterm. Group B showed significantly higher (p < 0.0001) rate of CRP, bacterial vaginosis, and chorioamnionitis at placental histological examination than Group A. The same parameters were statistically higher (p < 0.0001) in group B1 than in B3. CRP, chorioamnionitis at placental histological examination was statistically higher (p < 0.0001) in Group B early than in Group B late. Conclusions. This retrospective study suggested that in women affected by preterm labor, the long-term tocolysis with intravenous ritodrine is able to prolong gestation beyond 7 days, in absence of inflammatory/infective risk factors of PTD. © 2011 Informa UK, Ltd.
2011
Torricelli, M., Voltolini, C., Conti, N., De Bonis, M., Biliotti, G., Picciolini, E., et al. (2011). Inflammatory and infectious risk factors are associated with the response to tocolysis in patients with preterm labor. THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 24(1), 43-46 [10.3109/14767058.2010.482614].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/20559
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