Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CRF and urocortin inhibit placental system A activity. Chronic (48 h) exposure of term placental villous explants to these hormones (10 -7 M) significantly reduced system A activity (Na+- dependent 14C-methylaminoisobutyric acid uptake), whereas 1 h exposure had no effect. We propose elevated CRF and urocortin contribute to FGR through negative regulation of placental system A activity. © 2010 Elsevier Ltd. All rights reserved.
Giovannelli, A., Greenwood, S.L., Desforges, M., Sibley, C.P., Petraglia, F. (2011). Corticotrophin-releasing factor and urocortin inhibit system A activity in term human placental villous explants. PLACENTA, 32(1), 99-101 [10.1016/j.placenta.2010.10.015].
Corticotrophin-releasing factor and urocortin inhibit system A activity in term human placental villous explants
Giovannelli, A.;Petraglia, F.
2011-01-01
Abstract
Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CRF and urocortin inhibit placental system A activity. Chronic (48 h) exposure of term placental villous explants to these hormones (10 -7 M) significantly reduced system A activity (Na+- dependent 14C-methylaminoisobutyric acid uptake), whereas 1 h exposure had no effect. We propose elevated CRF and urocortin contribute to FGR through negative regulation of placental system A activity. © 2010 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/20517
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo