Background and Objective: The degree of cycle control achieved with a hormonal contraceptive method is an important determinant of its acceptance and continuation. This study set out to compare the cycle control and bleeding profile of drospirenone (DRSP) 3μg/ethinylestradiol (EE) 20 mg in a 24-active pill/4-inert pill (24/4) regimen (YAZ®) with those of desogestrel (DSG) 150 μg/EE 20 mg in a 21/7 regimen (Mercilon®), an established European combined oral contraceptive (COC). Methods: Bleeding data from women aged 1736 years who received either DRSP 3μg/EE 20 mg in a 24/4 regimen (n = 1285) or DSG 150 μg/EE 20 mg in a 21/7 regimen (n = 471) during four clinical studies were pooled and analysed over seven treatment cycles. Results: The maximum intensity of scheduled withdrawal bleeding was normal bleeding for <50%of subjects in cycles 16 in both treatment groups. Moreover, the incidence of unscheduled intracyclic bleeding during cycles 27 was comparable between treatment types (10.214.9% in women treated with DRSP 3μg/EE 20 mg 24/4 vs 8.613.8% in women treated with DSG 150 μg/EE 20 mg 21/7). Overall, similar bleeding patterns were observed with both treatments. Conclusion: DRSP 3μg/EE 20 mg 24/4 is associated with a bleeding profile and cycle control that is comparable to that of an established, low-dose COC formulation. © 2011 Adis Data Information BV. All rights reserved. Combined-oral-contraceptives; Ethinylestradioldesogestrel; Ethinylestradioldrospirenone.

Anttila, L., Neunteufel, W., Petraglia, F., Marr, J., Kunz, M. (2011). Cycle control and bleeding pattern of a 24/4 regimen of drospirenone 3 mg/ethinylestradiol 20 μg compared with a 21/7 regimen of desogestrel 150 μg/ethinylestradiol 20 μg: a pooled analysis. CLINICAL DRUG INVESTIGATION, 31(8), 519-525 [10.2165/11590260-000000000-00000].

Cycle control and bleeding pattern of a 24/4 regimen of drospirenone 3 mg/ethinylestradiol 20 μg compared with a 21/7 regimen of desogestrel 150 μg/ethinylestradiol 20 μg: a pooled analysis

Petraglia, F.;
2011-01-01

Abstract

Background and Objective: The degree of cycle control achieved with a hormonal contraceptive method is an important determinant of its acceptance and continuation. This study set out to compare the cycle control and bleeding profile of drospirenone (DRSP) 3μg/ethinylestradiol (EE) 20 mg in a 24-active pill/4-inert pill (24/4) regimen (YAZ®) with those of desogestrel (DSG) 150 μg/EE 20 mg in a 21/7 regimen (Mercilon®), an established European combined oral contraceptive (COC). Methods: Bleeding data from women aged 1736 years who received either DRSP 3μg/EE 20 mg in a 24/4 regimen (n = 1285) or DSG 150 μg/EE 20 mg in a 21/7 regimen (n = 471) during four clinical studies were pooled and analysed over seven treatment cycles. Results: The maximum intensity of scheduled withdrawal bleeding was normal bleeding for <50%of subjects in cycles 16 in both treatment groups. Moreover, the incidence of unscheduled intracyclic bleeding during cycles 27 was comparable between treatment types (10.214.9% in women treated with DRSP 3μg/EE 20 mg 24/4 vs 8.613.8% in women treated with DSG 150 μg/EE 20 mg 21/7). Overall, similar bleeding patterns were observed with both treatments. Conclusion: DRSP 3μg/EE 20 mg 24/4 is associated with a bleeding profile and cycle control that is comparable to that of an established, low-dose COC formulation. © 2011 Adis Data Information BV. All rights reserved. Combined-oral-contraceptives; Ethinylestradioldesogestrel; Ethinylestradioldrospirenone.
2011
Anttila, L., Neunteufel, W., Petraglia, F., Marr, J., Kunz, M. (2011). Cycle control and bleeding pattern of a 24/4 regimen of drospirenone 3 mg/ethinylestradiol 20 μg compared with a 21/7 regimen of desogestrel 150 μg/ethinylestradiol 20 μg: a pooled analysis. CLINICAL DRUG INVESTIGATION, 31(8), 519-525 [10.2165/11590260-000000000-00000].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/20486
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