Poly-BF3a, a new hydrophobic polymer obtained by spontaneous polymerization of 1-methylene-3-phenyl-1H-indene, was found to give nanoparticles characterized by favorable shape and dimensions. Poly-BF3a nanoparticles were loaded with CR3124, a potent 5HT(3) antagonist, as a drug model by desolvation methods either in the absence or in the presence of polyethylene glycol (PEG1000) as a wetting agent. The SEM studies showed that the introduction of CR3124 into the preparation led to a variable degree of aggregation-cementation, which afforded a sort of nanocomposite material. In the absence of PEG1000, the drug molecule was found to stay in the amorphous state (DSC studies) when its percentage is not higher than 10% by weight. In vitro release experiments showed that the formation and stability of the dispersion as well as the drug release were remarkably affected by the presence of PEG1000, demonstrating its beneficial effect to the nanoparticle morphology and disaggregation.

Cappelli, A., Galeazzi, S., Zanardi, I., Travagli, V., Anzini, M., Mendichi, R., et al. (2010). A Nanocomposite Material Formed by Benzofulvene Polymer Nanoparticles Loaded with a Potent 5-HT3 Receptor Antagonist (CR3124). JOURNAL OF NANOPARTICLE RESEARCH, 12(3), 895-903 [10.1007/s11051-009-9638-6].

A Nanocomposite Material Formed by Benzofulvene Polymer Nanoparticles Loaded with a Potent 5-HT3 Receptor Antagonist (CR3124)

Cappelli, Andrea;Zanardi, Iacopo;Travagli, Valter;Anzini, Maurizio;Paccagnini, Eugenio;Vomero, Salvatore
2010-01-01

Abstract

Poly-BF3a, a new hydrophobic polymer obtained by spontaneous polymerization of 1-methylene-3-phenyl-1H-indene, was found to give nanoparticles characterized by favorable shape and dimensions. Poly-BF3a nanoparticles were loaded with CR3124, a potent 5HT(3) antagonist, as a drug model by desolvation methods either in the absence or in the presence of polyethylene glycol (PEG1000) as a wetting agent. The SEM studies showed that the introduction of CR3124 into the preparation led to a variable degree of aggregation-cementation, which afforded a sort of nanocomposite material. In the absence of PEG1000, the drug molecule was found to stay in the amorphous state (DSC studies) when its percentage is not higher than 10% by weight. In vitro release experiments showed that the formation and stability of the dispersion as well as the drug release were remarkably affected by the presence of PEG1000, demonstrating its beneficial effect to the nanoparticle morphology and disaggregation.
2010
Cappelli, A., Galeazzi, S., Zanardi, I., Travagli, V., Anzini, M., Mendichi, R., et al. (2010). A Nanocomposite Material Formed by Benzofulvene Polymer Nanoparticles Loaded with a Potent 5-HT3 Receptor Antagonist (CR3124). JOURNAL OF NANOPARTICLE RESEARCH, 12(3), 895-903 [10.1007/s11051-009-9638-6].
File in questo prodotto:
File Dimensione Formato  
106226_UPLOAD.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 416.52 kB
Formato Adobe PDF
416.52 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/19042
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo