A series of novel enantiomerically pure azole derivatives was synthesized. The new compounds, bearing both an imidazole as well as a triazole moiety, were evaluated as antimycobacterial agents. One of them proved to have activity against Mycobaterium tuberculosis comparable to those of the classical antibacterial/antifungal drugs Econazole and Clotrimazole.
Castagnolo, D., Botta, M., Dessì, F., Manetti, F., Saddi, M., Meleddu, R., et al. (2009). Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19, 2203-2205 [10.1016/j.bmcl.2009.02.101].
Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis
BOTTA, MAURIZIO;MANETTI, FABRIZIO;
2009-01-01
Abstract
A series of novel enantiomerically pure azole derivatives was synthesized. The new compounds, bearing both an imidazole as well as a triazole moiety, were evaluated as antimycobacterial agents. One of them proved to have activity against Mycobaterium tuberculosis comparable to those of the classical antibacterial/antifungal drugs Econazole and Clotrimazole.
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https://hdl.handle.net/11365/18940
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