The title compound, C22H23N3O.0.13H2O, is a novel potent and selective serotonin 5-HT3 receptor antagonist. Three independent molecules constitute the asymmetric unit. While two of these molecules show only small differences in their metric and conformational parameters, the third differs from the other two, mainly as a result of the conformation of the oxepine ring. The conformations of the seven-membered ring determine quite different orientations of the oxepine-fused benzene ring, whose role is important in the exploitation of biological activity.

Giorgi, G., Cappelli, A., Anzini, M., Vomero, S., Marchetti, F. (1997). Characterization of Quinoline Derivatives. I. 6,7-Dihydro-8-(4-methyl-1-piperazinyl)[1]benzoxepino[4,5-c]quinoline 0.13-Hydrate. ACTA CRYSTALLOGRAPHICA. SECTION C, CRYSTAL STRUCTURE COMMUNICATIONS, C53(7), 987-990 [10.1107/S0108270196014564].

Characterization of Quinoline Derivatives. I. 6,7-Dihydro-8-(4-methyl-1-piperazinyl)[1]benzoxepino[4,5-c]quinoline 0.13-Hydrate

Giorgi, Gianluca;Cappelli, Andrea;Anzini, Maurizio;Vomero, Salvatore;
1997-01-01

Abstract

The title compound, C22H23N3O.0.13H2O, is a novel potent and selective serotonin 5-HT3 receptor antagonist. Three independent molecules constitute the asymmetric unit. While two of these molecules show only small differences in their metric and conformational parameters, the third differs from the other two, mainly as a result of the conformation of the oxepine ring. The conformations of the seven-membered ring determine quite different orientations of the oxepine-fused benzene ring, whose role is important in the exploitation of biological activity.
1997
Giorgi, G., Cappelli, A., Anzini, M., Vomero, S., Marchetti, F. (1997). Characterization of Quinoline Derivatives. I. 6,7-Dihydro-8-(4-methyl-1-piperazinyl)[1]benzoxepino[4,5-c]quinoline 0.13-Hydrate. ACTA CRYSTALLOGRAPHICA. SECTION C, CRYSTAL STRUCTURE COMMUNICATIONS, C53(7), 987-990 [10.1107/S0108270196014564].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/17739
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo