The rising prevalence of metabolic diseases related to insulin resistance (IR) have stressed the urgent need of accurate and applicable tools for early diagnosis and treatment. In the last decade, non-coding RNAs (ncRNAs) have gained growing interest because of their potential role in IR modulation. NcRNAs are variable-length transcripts which are not translated into proteins but are involved in gene expression regulation. Thanks to their stability and easy detection in biological fluids, ncRNAs have been investigated as promising diagnostic and therapeutic markers in metabolic diseases, such as type 2 diabetes mellitus (T2D), obesity and non-alcoholic fatty liver disease (NAFLD). Here we review the emerging role of ncRNAs in the development of IR and related diseases such as obesity, T2D and NAFLD, and summarize current evidence concerning their potential clinical application.

Formichi, C., Nigi, L., Grieco, G.E., Maccora, C., Fignani, D., Brusco, N., et al. (2021). Non-coding RNAs: novel players in insulin resistance and related diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14) [10.3390/ijms22147716].

Non-coding RNAs: novel players in insulin resistance and related diseases

Formichi, Caterina;Nigi, Laura;Grieco, Giuseppina Emanuela;Maccora, Carla;Fignani, Daniela;Brusco, Noemi;Licata, Giada;Sebastiani, Guido;Dotta, Francesco
2021-01-01

Abstract

The rising prevalence of metabolic diseases related to insulin resistance (IR) have stressed the urgent need of accurate and applicable tools for early diagnosis and treatment. In the last decade, non-coding RNAs (ncRNAs) have gained growing interest because of their potential role in IR modulation. NcRNAs are variable-length transcripts which are not translated into proteins but are involved in gene expression regulation. Thanks to their stability and easy detection in biological fluids, ncRNAs have been investigated as promising diagnostic and therapeutic markers in metabolic diseases, such as type 2 diabetes mellitus (T2D), obesity and non-alcoholic fatty liver disease (NAFLD). Here we review the emerging role of ncRNAs in the development of IR and related diseases such as obesity, T2D and NAFLD, and summarize current evidence concerning their potential clinical application.
2021
Formichi, C., Nigi, L., Grieco, G.E., Maccora, C., Fignani, D., Brusco, N., et al. (2021). Non-coding RNAs: novel players in insulin resistance and related diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14) [10.3390/ijms22147716].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1220879