An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields.

Saletti, M., Paolino, M., Ballerini, L., Giuliani, G., Leone, G., Lamponi, S., et al. (2022). Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers. PHARMACEUTICS, 14(5), 1041 [10.3390/pharmaceutics14051041].

Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers

Saletti, Mario;Paolino, Marco;Ballerini, Lavinia;Giuliani, Germano;Leone, Gemma;Lamponi, Stefania;Andreassi, Marco;Bonechi, Claudia;Donati, Alessandro;Magnani, Agnese;Cappelli, Andrea
2022-01-01

Abstract

An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields.
Saletti, M., Paolino, M., Ballerini, L., Giuliani, G., Leone, G., Lamponi, S., et al. (2022). Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers. PHARMACEUTICS, 14(5), 1041 [10.3390/pharmaceutics14051041].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1216634
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