Mechanistic Aspects of the Asymmetric Transfer Hydrogenation in the Manufacture of Noradrenaline

Mechanistic, stereochemical and stereoelectronic aspects of the asymmetric reduction (via hydrogen or transfer hydrogenation) for the manufacture of N-benzyl-noradrenaline from the ketone precursor are studied through catalyst screening and computational evaluations. This reaction provides an efficient and industrially suitable method for the manufacture of enantiomerically pure noradrenaline, an important neurotransmitter which is widely used as a pharmacological substance due to its sympathomimetic properties. © 2022 Wiley-VCH GmbH.