It is well known that castration in rats causes atrophy of the sexual organs and, to a lesser extent, of other organs. We have observed that castration causes a reduction of the liver weight due to a reduction (-10%) of the numerical density of the hepatocytes after castration (p less than 0.01). Testosterone administration at high concentration (2.5 mg/100 g b. wt.) as well as at low concentration (0.025 mg/100 g) in the castrated rats causes an increase of the liver weight due to an increase (+30%) in the cellular area (p less than 0.001) as well as in the nuclear area (+20%) (p less than 0.01) of the hepatocytes, revealing a powerful hypertrophic effect of the hormone in the liver.
Tanganelli, P., Bianciardi, G., Barbagli, L., Paffetti, A., Di Stefano, A., Pizzichini, M., et al. (1991). Effects of testosterone on the liver of castrated rats. Morphologic study. EXPERIMENTAL PATHOLOGY, 43(1-2), 21-24 [10.1016/S0232-1513(11)80135-0].
Effects of testosterone on the liver of castrated rats. Morphologic study
Tanganelli P.;Bianciardi G.;Pizzichini M.;Marinello E.
1991-01-01
Abstract
It is well known that castration in rats causes atrophy of the sexual organs and, to a lesser extent, of other organs. We have observed that castration causes a reduction of the liver weight due to a reduction (-10%) of the numerical density of the hepatocytes after castration (p less than 0.01). Testosterone administration at high concentration (2.5 mg/100 g b. wt.) as well as at low concentration (0.025 mg/100 g) in the castrated rats causes an increase of the liver weight due to an increase (+30%) in the cellular area (p less than 0.001) as well as in the nuclear area (+20%) (p less than 0.01) of the hepatocytes, revealing a powerful hypertrophic effect of the hormone in the liver.
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https://hdl.handle.net/11365/11941
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