Thin layer chromatography in pharmaceutical quality control. Assay of inosiplex in different pharmaceutical forms

The authors describe an HPTLC concentration zone method developed for the quality control of Inosiplex in different pharmaceutical forms. The plates were found to have good operating capacity in terms of specificity, accuracy, reliability and reproducibility with respect to the three molecular components of the active principle. The coefficients of variation of inosine and p-aminobenzoic acid are between 0.5 and 0.7. The method was also satisfactory for the quality control of 1-(dimethylamino)-2-propanol. Also if evidentiation is performed directly on the eluted spot, the coefficients of variation are between 1.2 and 1.6 for the three pharmaceutical forms.