HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity on cell-based assays. Due to their low cytotoxicity, low molecular weight, drug-like properties, and structural novelty, we embarked on a study to optimize the original lead compounds.
Garofalo, A., Grande, F., Brizzi, A., Aiello, F., Dayam, R., Neamati, N. (2008). Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation. CHEMMEDCHEM, 3(6), 986-990 [10.1002/cmdc.200800026].
Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation
Brizzi A.;
2008-01-01
Abstract
HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity on cell-based assays. Due to their low cytotoxicity, low molecular weight, drug-like properties, and structural novelty, we embarked on a study to optimize the original lead compounds.
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https://hdl.handle.net/11365/11543
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