HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity on cell-based assays. Due to their low cytotoxicity, low molecular weight, drug-like properties, and structural novelty, we embarked on a study to optimize the original lead compounds.
Antonio, G., Fedora, G., Francesca, A., Raveendra, D., Nouri, N., Brizzi, A. (2008). Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation. CHEMMEDCHEM, 3, 986-990 [10.1002/cmdc.200800026].
Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation
BRIZZI, ANTONELLA
2008-01-01
Abstract
HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity on cell-based assays. Due to their low cytotoxicity, low molecular weight, drug-like properties, and structural novelty, we embarked on a study to optimize the original lead compounds.
| File | Dimensione | Formato | |
|---|---|---|---|
|
ChemMedChem 2008.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
238.68 kB
Formato
Adobe PDF
|
238.68 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/11543
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo