HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity on cell-based assays. Due to their low cytotoxicity, low molecular weight, drug-like properties, and structural novelty, we embarked on a study to optimize the original lead compounds.

Antonio, G., Fedora, G., Francesca, A., Raveendra, D., Nouri, N., & Brizzi, A. (2008). Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation. CHEMMEDCHEM, 3, 986-990 [10.1002/cmdc.200800026].

Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation

BRIZZI, ANTONELLA
2008

Abstract

HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity on cell-based assays. Due to their low cytotoxicity, low molecular weight, drug-like properties, and structural novelty, we embarked on a study to optimize the original lead compounds.
Antonio, G., Fedora, G., Francesca, A., Raveendra, D., Nouri, N., & Brizzi, A. (2008). Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation. CHEMMEDCHEM, 3, 986-990 [10.1002/cmdc.200800026].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/11543
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