A novel "Keppler type" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound. © 2007 American Chemical Society.

Mura, P., Camalli, M., Bindoli, A., Sorrentino, F., Casini, A., Gabbiani, C., et al. (2007). Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound. JOURNAL OF MEDICINAL CHEMISTRY, 50(24), 5871-5874 [10.1021/jm0708578].

Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound

Corsini M.;Zanello P.;
2007-01-01

Abstract

A novel "Keppler type" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound. © 2007 American Chemical Society.
Mura, P., Camalli, M., Bindoli, A., Sorrentino, F., Casini, A., Gabbiani, C., et al. (2007). Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound. JOURNAL OF MEDICINAL CHEMISTRY, 50(24), 5871-5874 [10.1021/jm0708578].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1143937
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