We studied interactions of nitromusk compounds musk ketone and musk xylene and polycyclic musks Galaxolide™ (HHCB), Celestolide™ (ADBI), Tetralide™ (AHTN), and Traseolide™ (AITI) with multixenobiotic resistance (mxr) transporters in gill tissue of the marine mussel Mytilus californianus (Conrad, 1837). A competitive substrate transport test with rhodamine B was used to assay modulation of transport activity by musks. All tested musks inhibited the transport activity in the low μm range as indicated by increased accumulation of rhodamine B in the tissue. Compared to known substrates of mxr transporters, the effective concentration range was similar to quinidine and about 100 times higher than verapamil. Musk ketone and musk xylene also inhibited efflux of rhodamine B from gill tissue which was loaded with the dye and subsequently incubated with these compounds. Synthetic musk compounds are persistent environmental pollutants in aquatic environments with a high potential to bioaccumulate. As potent inhibitors of mxr transporters they may also play a role as chemosensitizers that enable toxic mxr substrates to accumulate in cells of aquatic organisms. © 2004 Elsevier Ltd. All rights reserved.

Luckenbach, T., Corsi, I., & Epel, D. (2004). Fatal odors: synthetic musk fragrances compromise multixenobiotic defense mechanisms in mussels. MARINE ENVIRONMENTAL RESEARCH, 58(2-5), 215-219 [10.1016/j.marenvres.2004.03.017].

Fatal odors: synthetic musk fragrances compromise multixenobiotic defense mechanisms in mussels

CORSI, I.;
2004

Abstract

We studied interactions of nitromusk compounds musk ketone and musk xylene and polycyclic musks Galaxolide™ (HHCB), Celestolide™ (ADBI), Tetralide™ (AHTN), and Traseolide™ (AITI) with multixenobiotic resistance (mxr) transporters in gill tissue of the marine mussel Mytilus californianus (Conrad, 1837). A competitive substrate transport test with rhodamine B was used to assay modulation of transport activity by musks. All tested musks inhibited the transport activity in the low μm range as indicated by increased accumulation of rhodamine B in the tissue. Compared to known substrates of mxr transporters, the effective concentration range was similar to quinidine and about 100 times higher than verapamil. Musk ketone and musk xylene also inhibited efflux of rhodamine B from gill tissue which was loaded with the dye and subsequently incubated with these compounds. Synthetic musk compounds are persistent environmental pollutants in aquatic environments with a high potential to bioaccumulate. As potent inhibitors of mxr transporters they may also play a role as chemosensitizers that enable toxic mxr substrates to accumulate in cells of aquatic organisms. © 2004 Elsevier Ltd. All rights reserved.
Luckenbach, T., Corsi, I., & Epel, D. (2004). Fatal odors: synthetic musk fragrances compromise multixenobiotic defense mechanisms in mussels. MARINE ENVIRONMENTAL RESEARCH, 58(2-5), 215-219 [10.1016/j.marenvres.2004.03.017].
File in questo prodotto:
File Dimensione Formato  
Luckenbach MER 2004.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 155.11 kB
Formato Adobe PDF
155.11 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/11428
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo