Some heterocyclic analogs of suramin with potent and selective basic fibroblast growth factor (bFGF) complexing activity have been synthesized. The possible mode of action of these compounds, deduced on the basis of SAR, biological properties and molecular modeling studies, entails a unique bidentate binding of the ligands to both the heparin and receptor binding sites of the growth factor
G., B., Botta, M., M., C., Corelli, F., M., G., Manetti, F., et al. (1994). New Heterocyclic Analogs of Suramin with bFGF Inhibiting Activity. Synthesis, SAR and Possible Mode of Action. MEDICINAL CHEMISTRY RESEARCH, 4, 202-210.
New Heterocyclic Analogs of Suramin with bFGF Inhibiting Activity. Synthesis, SAR and Possible Mode of Action
BOTTA, MAURIZIO;CORELLI, FEDERICO;MANETTI, FABRIZIO;
1994-01-01
Abstract
Some heterocyclic analogs of suramin with potent and selective basic fibroblast growth factor (bFGF) complexing activity have been synthesized. The possible mode of action of these compounds, deduced on the basis of SAR, biological properties and molecular modeling studies, entails a unique bidentate binding of the ligands to both the heparin and receptor binding sites of the growth factor
| File | Dimensione | Formato | |
|---|---|---|---|
|
1998BioorgMedChemSuradista.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
447.22 kB
Formato
Adobe PDF
|
447.22 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/11146
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo