Some heterocyclic analogs of suramin with potent and selective basic fibroblast growth factor (bFGF) complexing activity have been synthesized. The possible mode of action of these compounds, deduced on the basis of SAR, biological properties and molecular modeling studies, entails a unique bidentate binding of the ligands to both the heparin and receptor binding sites of the growth factor
G., B., Botta, M., M., C., Corelli, F., M., G., Manetti, F., et al. (1994). New Heterocyclic Analogs of Suramin with bFGF Inhibiting Activity. Synthesis, SAR and Possible Mode of Action. MEDICINAL CHEMISTRY RESEARCH, 4, 202-210 [10.1016/S0968-0896(98)00052-2].
New Heterocyclic Analogs of Suramin with bFGF Inhibiting Activity. Synthesis, SAR and Possible Mode of Action
BOTTA, MAURIZIO;CORELLI, FEDERICO;MANETTI, FABRIZIO;
1994-01-01
Abstract
Some heterocyclic analogs of suramin with potent and selective basic fibroblast growth factor (bFGF) complexing activity have been synthesized. The possible mode of action of these compounds, deduced on the basis of SAR, biological properties and molecular modeling studies, entails a unique bidentate binding of the ligands to both the heparin and receptor binding sites of the growth factor
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https://hdl.handle.net/11365/11146
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