Serum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different lung diseases, including autoimmune disorders, chronic obstructive pulmonary diseases, obstructive sleep apnea syndrome, sarcoidosis, asthma, lung cancer, and other lung disorders, such as idiopathic pulmonary fibrosis, tuberculosis, radiation pneumonitis, and cystic fibrosis. This review focuses on the cellular and molecular interactions of serum amyloid A in different lung diseases and suggests this acute-phase protein as a prognostic marker.

Vietri, L., Fui, A., Bergantini, L., D'Alessandro, M., Cameli, P., Sestini, P., et al. (2020). Serum amyloid A: A potential biomarker of lung disorders. RESPIRATORY INVESTIGATION, 58(1), 21-27 [10.1016/j.resinv.2019.09.005].

Serum amyloid A: A potential biomarker of lung disorders

Vietri, Lucia;Fui, Annalisa;Bergantini, Laura;d'Alessandro, Miriana;Cameli, Paolo;Sestini, Piersante;Rottoli, Paola;Bargagli, Elena
2020-01-01

Abstract

Serum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different lung diseases, including autoimmune disorders, chronic obstructive pulmonary diseases, obstructive sleep apnea syndrome, sarcoidosis, asthma, lung cancer, and other lung disorders, such as idiopathic pulmonary fibrosis, tuberculosis, radiation pneumonitis, and cystic fibrosis. This review focuses on the cellular and molecular interactions of serum amyloid A in different lung diseases and suggests this acute-phase protein as a prognostic marker.
2020
Vietri, L., Fui, A., Bergantini, L., D'Alessandro, M., Cameli, P., Sestini, P., et al. (2020). Serum amyloid A: A potential biomarker of lung disorders. RESPIRATORY INVESTIGATION, 58(1), 21-27 [10.1016/j.resinv.2019.09.005].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1086172