A thixotropic polyvinyl alcohol (PVA) hydrogel, containing a hydrophilic poly-vinyl pyrrolidone (PVP) core, was obtained in order to develop a preformed 3D network able to maintain injectability. PVA was mixed with PVP in two different molar ratios (1:1 and 1:3) and chemically cross-linked using trisodium trimetaphosphate (STMP), which is able to react only with PVA component. A combination of Time of Flight- Secondary Ion Mass Spectrometry (ToF-SIMS), elemental analysis and UV spectroscopy permitted to determine both the cross-linking arm length and the crosslinking degree. Hydrogels were characterized in terms of swelling pressurization, rheological and mechanical behaviour. In particular, the viscoelastic behaviour of the hydrogel was analysed in shear and compression stress under dynamic conditions and compared with the performance of healthy human nucleus pulposus. In conclusion, the study demonstrated that the scaffold obtained mixing PVA and PVP in a molar ratio 1:1 can be considered a promising material to be utilised in the replacement of nucleus pulposus.

Leone, G., Rossi, C., Donati, A., Consumi, M., Lamponi, S., Magnani, A., et al. (2019). Thixotropic PVA hydrogel enclosing a hydrophilic PVP core as nucleus pulposus substitute. MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS, 98, 696-704 [10.1016/j.msec.2019.01.039].

Thixotropic PVA hydrogel enclosing a hydrophilic PVP core as nucleus pulposus substitute

G. Leone
;
C. Rossi;A. Donati;M. Consumi;S. Lamponi;A. Magnani
;
G. TAMASI;C. Bonechi
2019-01-01

Abstract

A thixotropic polyvinyl alcohol (PVA) hydrogel, containing a hydrophilic poly-vinyl pyrrolidone (PVP) core, was obtained in order to develop a preformed 3D network able to maintain injectability. PVA was mixed with PVP in two different molar ratios (1:1 and 1:3) and chemically cross-linked using trisodium trimetaphosphate (STMP), which is able to react only with PVA component. A combination of Time of Flight- Secondary Ion Mass Spectrometry (ToF-SIMS), elemental analysis and UV spectroscopy permitted to determine both the cross-linking arm length and the crosslinking degree. Hydrogels were characterized in terms of swelling pressurization, rheological and mechanical behaviour. In particular, the viscoelastic behaviour of the hydrogel was analysed in shear and compression stress under dynamic conditions and compared with the performance of healthy human nucleus pulposus. In conclusion, the study demonstrated that the scaffold obtained mixing PVA and PVP in a molar ratio 1:1 can be considered a promising material to be utilised in the replacement of nucleus pulposus.
2019
Leone, G., Rossi, C., Donati, A., Consumi, M., Lamponi, S., Magnani, A., et al. (2019). Thixotropic PVA hydrogel enclosing a hydrophilic PVP core as nucleus pulposus substitute. MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS, 98, 696-704 [10.1016/j.msec.2019.01.039].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1072189