Rett syndrome (RTT) is a devastating genetic neurodevelopmental disorder, previously classified among the autism spectrum disorders. It is caused by sporadic mutations in the X-linked gene encoding the methyl-CpG binding protein 2 (MeCP2) and affects almost exclusively females. However, the mechanisms leading from gene mutations to phenotypical expression remain incompletely clarified and a definitive cure is still lacking. Oxidative events accompanying the RTT can modify the anti-inflammatory properties of the high density lipoproteins rendering them pro-inflammatory. Oxidative stress (OS) is known to be related to decreased expression of OS inhibitors as well as over-expression of positive acute phase response proteins. Prior investigations suggest that ω-3 polyunsaturated fatty acids (ω-3 PUFAs), natural multifunctional antioxidants, exert a beneficial effect in patients affected by RTT, both in term of symptoms severity and redox imbalance. In the present study we examined plasma proteome changes in RTT subjects, with a particular focus on the proteins involved in the inflammatory cascade. Applying routine clinical chemistry and proteomics methods, we were able to document a subclinical inflammatory status in RTT patients, which was reversed by ω-3 PUFAs supplementation. Our findings provide new insight on the role of inflammation in neurodevelopmental disorders and indicate that ω-3 PUFAs-containing fish oil is able to modulate the expression of plasma proteins in RTT.

Cortelazzo, A., De Felice, C., Signorini, C., Guerranti, R., Leoncini, S., Pecorelli, A., et al. (2014). Acidi grassi polinsaturi ω-3 e stato infiammatorio subclinico nella sindrome di Rett: Un approccio proteomico. L'INTEGRATORE NUTRIZIONALE, 17(3), 26-34.

Acidi grassi polinsaturi ω-3 e stato infiammatorio subclinico nella sindrome di Rett: Un approccio proteomico

A. Cortelazzo;C. Signorini;R. Guerranti;S. Leoncini;A. Pecorelli;C. Landi;L. Bini;L Ciccoli;
2014-01-01

Abstract

Rett syndrome (RTT) is a devastating genetic neurodevelopmental disorder, previously classified among the autism spectrum disorders. It is caused by sporadic mutations in the X-linked gene encoding the methyl-CpG binding protein 2 (MeCP2) and affects almost exclusively females. However, the mechanisms leading from gene mutations to phenotypical expression remain incompletely clarified and a definitive cure is still lacking. Oxidative events accompanying the RTT can modify the anti-inflammatory properties of the high density lipoproteins rendering them pro-inflammatory. Oxidative stress (OS) is known to be related to decreased expression of OS inhibitors as well as over-expression of positive acute phase response proteins. Prior investigations suggest that ω-3 polyunsaturated fatty acids (ω-3 PUFAs), natural multifunctional antioxidants, exert a beneficial effect in patients affected by RTT, both in term of symptoms severity and redox imbalance. In the present study we examined plasma proteome changes in RTT subjects, with a particular focus on the proteins involved in the inflammatory cascade. Applying routine clinical chemistry and proteomics methods, we were able to document a subclinical inflammatory status in RTT patients, which was reversed by ω-3 PUFAs supplementation. Our findings provide new insight on the role of inflammation in neurodevelopmental disorders and indicate that ω-3 PUFAs-containing fish oil is able to modulate the expression of plasma proteins in RTT.
Cortelazzo, A., De Felice, C., Signorini, C., Guerranti, R., Leoncini, S., Pecorelli, A., et al. (2014). Acidi grassi polinsaturi ω-3 e stato infiammatorio subclinico nella sindrome di Rett: Un approccio proteomico. L'INTEGRATORE NUTRIZIONALE, 17(3), 26-34.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1051289