The enzyme steroid 5Î±-reductase 2 (5Î±R2) catalyzes the conversion of testosterone into the potent androgen 5Î±-dihydrotestosterone. Previous investigations showed that 5Î±R2 is expressed in key brain areas for emotional and socio-affective reactivity, yet the role of this enzyme in behavioral regulation remains mostly unknown. Here, we profiled the behavioral characteristics of 5Î±R2 heterozygous (HZ) and knockout (KO) mice, as compared with their wild-type (WT) littermates. While male 5Î±R2 KO mice displayed no overt alterations in motoric, sensory, information-processing and anxiety-related behaviors, they exhibited deficits in neurobehavioral correlates of dominance (including aggression against intruders, mating, and tube dominance) as well as novelty-seeking and risk-taking responses. Furthermore, male 5Î±R2 KO mice exhibited reduced D2-like dopamine receptor binding in the shell of the nucleus accumbens â a well-recognized molecular signature of social dominance. Collectively, these results suggest that 5Î±R2 is involved in the establishment of social dominance and its behavioral manifestations. Further studies are warranted to understand how the metabolic actions of 5Î±R2 on steroid profile may be implicated in social ranking, impulse control, and the modulation of dopamine receptor expression in the nucleus accumbens.
|Titolo:||Steroid 5alpha-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors|
|Citazione:||Mosher, L.J., Godar, S.C., Morissette, M., Mcfarlin, K.M., Scheggi, S., Gambarana, C., et al. (2018). Steroid 5alpha-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors. PSYCHONEUROENDOCRINOLOGY, 91, 95-104.|
|Appare nelle tipologie:||1.1 Articolo in rivista|