We report a procedure for the continuous-flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass-derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH12.0 at 90°C. By setting a packed reactor charged with the Pd/C catalyst (10wt%) at a flow rate of 0.5mLmin-1, we achieved continuous-flow production of cyclohexanone in high yield with high selectivity and productivity.

Valentini, F., Santillo, N., Petrucci, C., Lanari, D., Petricci, E., Taddei, M., et al. (2018). Continuous-Flow Palladium-Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source. CHEMCATCHEM, 10(6), 1277-1281 [10.1002/cctc.201701922].

Continuous-Flow Palladium-Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source

Santillo, Niccolò;Petricci, Elena;Taddei, Maurizio;
2018

Abstract

We report a procedure for the continuous-flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass-derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH12.0 at 90°C. By setting a packed reactor charged with the Pd/C catalyst (10wt%) at a flow rate of 0.5mLmin-1, we achieved continuous-flow production of cyclohexanone in high yield with high selectivity and productivity.
Valentini, F., Santillo, N., Petrucci, C., Lanari, D., Petricci, E., Taddei, M., et al. (2018). Continuous-Flow Palladium-Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source. CHEMCATCHEM, 10(6), 1277-1281 [10.1002/cctc.201701922].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/1038807