Aim: The preparation of a delivery system able to guarantee a delayed release of lovastatin from red yeast rice (RYR) is mandatory to counteract cholesterol biosynthesis effectively. Materials & methods: Polymeric formulations were prepared mixing alginate and gelatin, in different ratios, with RYR. The effect of different composition on stiffness, viscosity, swelling behavior and mesostructure of matrices was analyzed. Results: Formulations obtained combining polymers in comparable amount (i.e., 60/40 and 50/50) guaranteed a delayed release of lovastatin from RYR, a prolonged inhibitory activity toward 3-hydroxy-3-methylglutaryl-coenzyme A reductase and a decreased cholesterol synthesis. Conclusion: The formulation obtained combining 60% gelatin and 40% of alginate showed physicochemical properties suitable to lead a lovastatin release profile compatible with cholesterol biosynthesis.

Leone, G., Consumi, M., Pepi, S., Lamponi, S., Bonechi, C., Tamasi, G., et al. (2017). Alginate-gelatin formulation to modify lovastatin release profile from red yeast rice for hypercholesterolemia therapy. THERAPEUTIC DELIVERY, 8(10), 843-854 [10.4155/tde-2017-0025].

Alginate-gelatin formulation to modify lovastatin release profile from red yeast rice for hypercholesterolemia therapy

LEONE, GEMMA;CONSUMI, MARCO;PEPI, SIMONE;LAMPONI, STEFANIA;BONECHI, CLAUDIA;TAMASI, GABRIELLA;DONATI, ALESSANDRO;ROSSI, CLAUDIO;MAGNANI, AGNESE
2017-01-01

Abstract

Aim: The preparation of a delivery system able to guarantee a delayed release of lovastatin from red yeast rice (RYR) is mandatory to counteract cholesterol biosynthesis effectively. Materials & methods: Polymeric formulations were prepared mixing alginate and gelatin, in different ratios, with RYR. The effect of different composition on stiffness, viscosity, swelling behavior and mesostructure of matrices was analyzed. Results: Formulations obtained combining polymers in comparable amount (i.e., 60/40 and 50/50) guaranteed a delayed release of lovastatin from RYR, a prolonged inhibitory activity toward 3-hydroxy-3-methylglutaryl-coenzyme A reductase and a decreased cholesterol synthesis. Conclusion: The formulation obtained combining 60% gelatin and 40% of alginate showed physicochemical properties suitable to lead a lovastatin release profile compatible with cholesterol biosynthesis.
Leone, G., Consumi, M., Pepi, S., Lamponi, S., Bonechi, C., Tamasi, G., et al. (2017). Alginate-gelatin formulation to modify lovastatin release profile from red yeast rice for hypercholesterolemia therapy. THERAPEUTIC DELIVERY, 8(10), 843-854 [10.4155/tde-2017-0025].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1019156