Background While the role of beta (∼20 Hz), theta (∼5 Hz) and alpha (∼10 Hz) oscillations in the motor areas have been repeatedly associated with defined properties of motor performance, the investigation of gamma (∼40–90 Hz) oscillatory activity is a more recent and still not fully understood component of motor control physiology, despite its potential clinical relevance for motor disorders. Objective/hypothesis We have implemented an online neuromodulation paradigm based on transcranial alternating current stimulation (tACS) of the dominant motor cortex during a visuo-motor coordination task. This approach would allow a better understanding of the role of gamma activity, as well as that of other oscillatory bands, and their chronometry throughout the task. Methods We tested the effects of 5 Hz, 20 Hz, 60 Hz (mid-gamma) 80 Hz (high-gamma) and sham tACS on the performance of a sample of right-handed healthy volunteers, during a custom-made unimanual tracking task addressing several randomly occurring components of visuo-motor coordination (i.e., constant velocity or acceleration pursuits, turns, loops). Results Data showed a significant enhancement of motor performance during high-gamma stimulation – as well as a trending effect for mid-gamma – with the effect being prominent between 200 and 500 ms after rapid changes in tracking trajectory. No other effects during acceleration or steady pursuit were found. Conclusions Our findings posit a role for high-frequency motor cortex gamma oscillations during complex visuo-motor tasks involving the sudden rearrangement of motor plan/execution. Such a “prokinetic” effect of high-gamma stimulation might be worth to be tested in motor disorders, like Parkinson's disease, where the switching between different motor programs is impaired. © 2017 Elsevier Inc.

Santarnecchi, E., Biasella, A., Tatti, E., Rossi, A., Prattichizzo, D., Rossi, S. (2017). High-gamma oscillations in the motor cortex during visuo-motor coordination: A tACS interferential study. BRAIN RESEARCH BULLETIN, 131, 47-54 [10.1016/j.brainresbull.2017.03.006].

High-gamma oscillations in the motor cortex during visuo-motor coordination: A tACS interferential study

SANTARNECCHI, EMILIANO;BIASELLA, ALESSIA;ROSSI, ALESSANDRO;PRATTICHIZZO, DOMENICO;ROSSI, SIMONE
2017-01-01

Abstract

Background While the role of beta (∼20 Hz), theta (∼5 Hz) and alpha (∼10 Hz) oscillations in the motor areas have been repeatedly associated with defined properties of motor performance, the investigation of gamma (∼40–90 Hz) oscillatory activity is a more recent and still not fully understood component of motor control physiology, despite its potential clinical relevance for motor disorders. Objective/hypothesis We have implemented an online neuromodulation paradigm based on transcranial alternating current stimulation (tACS) of the dominant motor cortex during a visuo-motor coordination task. This approach would allow a better understanding of the role of gamma activity, as well as that of other oscillatory bands, and their chronometry throughout the task. Methods We tested the effects of 5 Hz, 20 Hz, 60 Hz (mid-gamma) 80 Hz (high-gamma) and sham tACS on the performance of a sample of right-handed healthy volunteers, during a custom-made unimanual tracking task addressing several randomly occurring components of visuo-motor coordination (i.e., constant velocity or acceleration pursuits, turns, loops). Results Data showed a significant enhancement of motor performance during high-gamma stimulation – as well as a trending effect for mid-gamma – with the effect being prominent between 200 and 500 ms after rapid changes in tracking trajectory. No other effects during acceleration or steady pursuit were found. Conclusions Our findings posit a role for high-frequency motor cortex gamma oscillations during complex visuo-motor tasks involving the sudden rearrangement of motor plan/execution. Such a “prokinetic” effect of high-gamma stimulation might be worth to be tested in motor disorders, like Parkinson's disease, where the switching between different motor programs is impaired. © 2017 Elsevier Inc.
2017
Santarnecchi, E., Biasella, A., Tatti, E., Rossi, A., Prattichizzo, D., Rossi, S. (2017). High-gamma oscillations in the motor cortex during visuo-motor coordination: A tACS interferential study. BRAIN RESEARCH BULLETIN, 131, 47-54 [10.1016/j.brainresbull.2017.03.006].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1006822