NACCI, VITO
NACCI, VITO
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one
2002-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Morelli, Elena; Minetti, Patrizia; Tinti, Ornella; Nacci, Vito
A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor
1994-01-01 Greco, Giovanni; Novellino, Ettore; Fiorini, Isabella; Nacci, Vito; Campiani, Giuseppe; Ciani, Silvia M.; Garofalo, Antonio; Bernasconi, Paola; Mennini, Tiziana
A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors
1995-01-01 Dalpiaz, Alessandro; Bertolasi, Valerio; Boreal, Pier Andrea; Nacci, Vito; Fiorini, Isabella; Campiani, Giuseppe; Mennini, Tiziana; Manzoni, Cristina; Novellino, Ettore; Greco, Giovanni
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring
2003-01-01 Gemma, Sandra; Butini, Stefania; Fattorusso, Caterina; Fiorini, Isabella; Nacci, Vito; Bellebaum, Katherine; Mckissic, Down; Saxena, Ashima; Campiani, Giuseppe
A rational approach to the design of selective substrates and potent non-transportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). New glutamate and aspartate analogues as potential neuroprotective agents
2001-01-01 Campiani, G.; De Angelis, M.; Armaroli, S.; Fattorusso, C.; Catalanotti, B.; Ramunno, A.; Nacci, V.; Novellino, E.; Grewer, C.; Ionescu, D.; Rauen, T.; Griffiths, R.
Activation of the c-Jun NH2 Terminal Kinase (JNK) Signalling Pathway is Essential During PBOX-6-Induced Apoptosis in Chronic Myelogenous leukemia (CML) Cells
2002-01-01 MC GEE, M.; Campiani, G.; Ramunno, A.; Williams, C; Zisterer, D; Nacci, V.; Lawler, M.
An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity
1996-01-01 Kozikowski, Alan P.; Campiani, Giuseppe; Nacci, Vito; Sega, Alessandro; Saxena, Ashima; Doctor, Bhupendra P.
Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: Absence of correlation with binding to the peripheral-type benzodiazepine binding site
1998-01-01 Zisterer, Daniela M.; Hance, Nicole; Campiani, Giuseppe; Garofalo, Antonio; Nacci, Vito; Williams, D. Clive
Benzothiazine and Benzothiazepine derivatives: synthesis and preliminary biological evaluation
1993-01-01 Garofalo, A.; Campiani, G.; Fiorini, I.; Nacci, V.
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR): From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers
1996-01-01 Campiani, Giuseppe; Fiorini, Isabella; De Filippis, Maria P.; Ciani, Silvia M.; Garofalo, Antonio; Nacci, Vito; Giorgi, Gianluca; Sega, Alessandro; Botta, Maurizio; Chiarini, Alberto; Budriesi, Roberta; Bruni, Giancarlo
Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6
2002-01-01 Mc Gee, Margaret M.; Hyland, Edel; Campiani, Giuseppe; Ramunno, Anna; Nacci, Vito; Zisterer, Daniela M.
Characterisation of 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties
2001-01-01 Campiani, G.; Morelli, E.; Nacci, V.; Fattorusso, C.; Ramunno, A.; Novellino, E.; Greenwood, J.; Liljefors, T.; Griffiths, R.; Sinclair, C.; Reavy, H.; Kristensen, A. S.; Pickering, D. S.; Schousboe, A.; Cagnotto, A.; Fumagalli, E.; Mennini, T.
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies
2008-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, G.; Sanna Coccone, Salvatore; Joshi, B.; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Fattorusso, E; Taglialatela Scafati, O.; Savini, Luisa; Taramelli, D.; Basilico, N.; Parapini, S.; Morace, G.; Yardley, V.; Croft, S.; Coletta, M.; Marini, S.; Fattorusso, Caterina
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials
2009-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B. P.; Kukreja, G.; Sanna Coccone, Salvatore; Bernetti, Matteo; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Taramelli, D.; Basilico, N.; Parapini, S.; Yardley, V.; Croft, S.; Kellere Maerki, S.; Rottmann, M.; Brun, R.; Coletta, M.; Marini, S.; Guiso, G.; Caccia, S.; Fattorusso, C.
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore
2007-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B.; Kukreja, G.; Persico, M.; Catalanotti, B.; Novellino, E.; Fattorusso, E; Nacci, Vito; Savini, Luisa; Taramelli, D.; Basilico, N.; Morace, G.; Yardley, V.; Fattorusso, C.
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents
2008-01-01 Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Sindu, Ros; Brindisi, Margherita; Savini, Luisa; Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors
2005-01-01 Campiani, Giuseppe; Fattorusso, C; Butini, Stefania; Gaeta, A; Agnusdei, M; Gemma, Sandra; Persico, M; Catalanotti, B; Savini, Luisa; Nacci, Vito; Novellino, E; Holloway, Hw; Greig, Nh; Belinskaya, T; Fedorko, Jm; Saxena, A.
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior
2009-01-01 Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Franceschini, Silvia; Trotta, Francesco; Borriello, Marianna; Ceres, Nicoletta; Sindu, Ros; Coccone, Salvatore Sanna; Bernetti, Matteo; De Angelis, Meri; Brindisi, Margherita; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Cagnotto, Alfredo; Mennini, Tiziana; Sandager-Nielsen, Karin; Andreasen, Jesper Tobias; Scheel-Kruger, Jorgen; Mikkelsen, Jens D.; Fattorusso, Caterina
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites
2006-01-01 Gemma, Sandra; Gabellieri, Emanuele; Huleatt, P.; Fattorusso, C.; Borriello, M.; Catalanotti, B.; Butini, Stefania; De Angelis, M.; Novellino, E.; Nacci, Vito; Belinskaya, T.; Saxena, Ashima; Campiani, Giuseppe
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors
2008-01-01 Butini, Stefania; Campiani, Giuseppe; Borriello, M.; Gemma, Sandra; Panico, Alessandro; Persico, M.; Catalanotti, B.; Ros, S.; Brindisi, Margherita; Agnusdei, M.; Fiorini, Isabella; Nacci, Vito; Novellino, E.; Belinskaya, T.; Saxena, A.; Fattorusso, C.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| 'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one | 1-gen-2002 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Morelli, Elena; Minetti, Patrizia; Tinti, Ornella; Nacci, Vito | - | |
| A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor | 1-gen-1994 | Greco, Giovanni; Novellino, Ettore; Fiorini, Isabella; Nacci, Vito; Campiani, Giuseppe; Ciani, Silvia M.; Garofalo, Antonio; Bernasconi, Paola; Mennini, Tiziana | - | |
| A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors | 1-gen-1995 | Dalpiaz, Alessandro; Bertolasi, Valerio; Boreal, Pier Andrea; Nacci, Vito; Fiorini, Isabella; Campiani, Giuseppe; Mennini, Tiziana; Manzoni, Cristina; Novellino, Ettore; Greco, Giovanni | - | |
| A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring | 1-gen-2003 | Gemma, Sandra; Butini, Stefania; Fattorusso, Caterina; Fiorini, Isabella; Nacci, Vito; Bellebaum, Katherine; Mckissic, Down; Saxena, Ashima; Campiani, Giuseppe | - | |
| A rational approach to the design of selective substrates and potent non-transportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). New glutamate and aspartate analogues as potential neuroprotective agents | 1-gen-2001 | Campiani, G.; De Angelis, M.; Armaroli, S.; Fattorusso, C.; Catalanotti, B.; Ramunno, A.; Nacci, V.; Novellino, E.; Grewer, C.; Ionescu, D.; Rauen, T.; Griffiths, R. | - | |
| Activation of the c-Jun NH2 Terminal Kinase (JNK) Signalling Pathway is Essential During PBOX-6-Induced Apoptosis in Chronic Myelogenous leukemia (CML) Cells | 1-gen-2002 | MC GEE, M.; Campiani, G.; Ramunno, A.; Williams, C; Zisterer, D; Nacci, V.; Lawler, M. | - | |
| An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity | 1-gen-1996 | Kozikowski, Alan P.; Campiani, Giuseppe; Nacci, Vito; Sega, Alessandro; Saxena, Ashima; Doctor, Bhupendra P. | - | |
| Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: Absence of correlation with binding to the peripheral-type benzodiazepine binding site | 1-gen-1998 | Zisterer, Daniela M.; Hance, Nicole; Campiani, Giuseppe; Garofalo, Antonio; Nacci, Vito; Williams, D. Clive | - | |
| Benzothiazine and Benzothiazepine derivatives: synthesis and preliminary biological evaluation | 1-gen-1993 | Garofalo, A.; Campiani, G.; Fiorini, I.; Nacci, V. | - | |
| Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR): From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers | 1-gen-1996 | Campiani, Giuseppe; Fiorini, Isabella; De Filippis, Maria P.; Ciani, Silvia M.; Garofalo, Antonio; Nacci, Vito; Giorgi, Gianluca; Sega, Alessandro; Botta, Maurizio; Chiarini, Alberto; Budriesi, Roberta; Bruni, Giancarlo | - | |
| Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6 | 1-gen-2002 | Mc Gee, Margaret M.; Hyland, Edel; Campiani, Giuseppe; Ramunno, Anna; Nacci, Vito; Zisterer, Daniela M. | - | |
| Characterisation of 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties | 1-gen-2001 | Campiani, G.; Morelli, E.; Nacci, V.; Fattorusso, C.; Ramunno, A.; Novellino, E.; Greenwood, J.; Liljefors, T.; Griffiths, R.; Sinclair, C.; Reavy, H.; Kristensen, A. S.; Pickering, D. S.; Schousboe, A.; Cagnotto, A.; Fumagalli, E.; Mennini, T. | - | |
| Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies | 1-gen-2008 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, G.; Sanna Coccone, Salvatore; Joshi, B.; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Fattorusso, E; Taglialatela Scafati, O.; Savini, Luisa; Taramelli, D.; Basilico, N.; Parapini, S.; Morace, G.; Yardley, V.; Croft, S.; Coletta, M.; Marini, S.; Fattorusso, Caterina | - | |
| Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials | 1-gen-2009 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B. P.; Kukreja, G.; Sanna Coccone, Salvatore; Bernetti, Matteo; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Taramelli, D.; Basilico, N.; Parapini, S.; Yardley, V.; Croft, S.; Kellere Maerki, S.; Rottmann, M.; Brun, R.; Coletta, M.; Marini, S.; Guiso, G.; Caccia, S.; Fattorusso, C. | - | |
| Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore | 1-gen-2007 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B.; Kukreja, G.; Persico, M.; Catalanotti, B.; Novellino, E.; Fattorusso, E; Nacci, Vito; Savini, Luisa; Taramelli, D.; Basilico, N.; Morace, G.; Yardley, V.; Fattorusso, C. | - | |
| Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents | 1-gen-2008 | Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Sindu, Ros; Brindisi, Margherita; Savini, Luisa; Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra | - | |
| Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors | 1-gen-2005 | Campiani, Giuseppe; Fattorusso, C; Butini, Stefania; Gaeta, A; Agnusdei, M; Gemma, Sandra; Persico, M; Catalanotti, B; Savini, Luisa; Nacci, Vito; Novellino, E; Holloway, Hw; Greig, Nh; Belinskaya, T; Fedorko, Jm; Saxena, A. | - | |
| Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior | 1-gen-2009 | Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Franceschini, Silvia; Trotta, Francesco; Borriello, Marianna; Ceres, Nicoletta; Sindu, Ros; Coccone, Salvatore Sanna; Bernetti, Matteo; De Angelis, Meri; Brindisi, Margherita; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Cagnotto, Alfredo; Mennini, Tiziana; Sandager-Nielsen, Karin; Andreasen, Jesper Tobias; Scheel-Kruger, Jorgen; Mikkelsen, Jens D.; Fattorusso, Caterina | - | |
| Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites | 1-gen-2006 | Gemma, Sandra; Gabellieri, Emanuele; Huleatt, P.; Fattorusso, C.; Borriello, M.; Catalanotti, B.; Butini, Stefania; De Angelis, M.; Novellino, E.; Nacci, Vito; Belinskaya, T.; Saxena, Ashima; Campiani, Giuseppe | - | |
| Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors | 1-gen-2008 | Butini, Stefania; Campiani, Giuseppe; Borriello, M.; Gemma, Sandra; Panico, Alessandro; Persico, M.; Catalanotti, B.; Ros, S.; Brindisi, Margherita; Agnusdei, M.; Fiorini, Isabella; Nacci, Vito; Novellino, E.; Belinskaya, T.; Saxena, A.; Fattorusso, C. | - |