The capacity to spread beyond the limits of the tissue in which it was originated and to survive is the prerogative of malignant tumors, the feature at the basis of the concept of malignancy. In 90% of cases, a colon cancer originates from its dysplastic precursor, the adenomatous polyp; evidence that 60-70% of that cancer is localized in the distal colon suggests that environmental factors affects the progression of the tumor, like the activation of HIF-1 transcription factor and the physiological hypoxia that exists in this environment. Here we describe the finding of a clinical case where a benign tubulovillous adenoma appears able to survive and colonize the colonic mucosa away from the primary lesion. It was supported by visual inspection, histological evidence and fractal analysis (each tested morphometrical parameters- box dimension,information dimension, mass dimension, perimeter-area dimension, algorithmic complexity- overlapped each other, p<0.03). If this finding will be confirmed in a high number of patients and by experimental studies, the current diagnostic/therapeutic approaches of the colon tumors should be modified, not only regarding colorectal adenomas, but also the superficial cancer of the large bowel

D, M., F, I., Bianciardi, G. (2015). Spreading of a colon adenoma: a case report. FRACTAL GEOMETRY AND NONLINEAR ANALYSIS IN MEDICINE AND BIOLOGY, 1(3), 123-127 [10.15761/FGNAMB.1000120].

Spreading of a colon adenoma: a case report

BIANCIARDI, GIORGIO
2015-01-01

Abstract

The capacity to spread beyond the limits of the tissue in which it was originated and to survive is the prerogative of malignant tumors, the feature at the basis of the concept of malignancy. In 90% of cases, a colon cancer originates from its dysplastic precursor, the adenomatous polyp; evidence that 60-70% of that cancer is localized in the distal colon suggests that environmental factors affects the progression of the tumor, like the activation of HIF-1 transcription factor and the physiological hypoxia that exists in this environment. Here we describe the finding of a clinical case where a benign tubulovillous adenoma appears able to survive and colonize the colonic mucosa away from the primary lesion. It was supported by visual inspection, histological evidence and fractal analysis (each tested morphometrical parameters- box dimension,information dimension, mass dimension, perimeter-area dimension, algorithmic complexity- overlapped each other, p<0.03). If this finding will be confirmed in a high number of patients and by experimental studies, the current diagnostic/therapeutic approaches of the colon tumors should be modified, not only regarding colorectal adenomas, but also the superficial cancer of the large bowel
2015
D, M., F, I., Bianciardi, G. (2015). Spreading of a colon adenoma: a case report. FRACTAL GEOMETRY AND NONLINEAR ANALYSIS IN MEDICINE AND BIOLOGY, 1(3), 123-127 [10.15761/FGNAMB.1000120].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/999420
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