Idiopathic pulmonary fibrosis (IPF) is a rare form of chronic, progressive fibrosing interstitial pneumonia of unknown cause. The aim of this cross-sectional study was to assess the prevalence of osteoporosis and fragility fracture in a population of adults with IPF and to identify whether any possible clinical and pulmonary function parameters may be associated with increased bone fragility. In 58 IPF patients (mean age 65.1 ± 9.1 years), we measured bone mineral density (BMD) of the lumbar spine, the femoral neck, and the entire hip. Moreover, the presence of vertebral fractures on a lateral chest X-ray study was evaluated, and a vertebral fracture burden was quantified using the spinal deformity index (SDI). As expected, osteoporosis was significantly more frequent in females with respect to males (57.9 vs 20.5 %, respectively), whereas the fractures prevailed in males with respect to females (38.5 vs 26.3 %, respectively). There were positive correlations between BMD at all skeletal sites and respiratory parameters; in particular for FVC % and DLCO % with BMD at femoral sub-regions. Moreover, we compared the average of DLCO (%) measure by values of SDI score that was higher in those patients with lower values of DLCO (%). The study shows a high prevalence of fragility with vertebral fractures in IPF patients, especially in males. Moreover, the vertebral fracture burden is associated with a worsening of FVC (%) and DLCO (%). Therefore, an evaluation of bone status is recommended, especially in those patients who are candidates for lung transplantation.

Caffarelli, C., Gonnelli, S., TOMAI PITINCA, M.D., Francolini, V., Fui, A., Bargagli, E., et al. (2016). Idiopathic pulmonary fibrosis a rare disease with severe bone fragility. INTERNAL AND EMERGENCY MEDICINE, 11(8), 1087-1094 [10.1007/s11739-016-1501-z].

Idiopathic pulmonary fibrosis a rare disease with severe bone fragility

CAFFARELLI, CARLA;GONNELLI, STEFANO;TOMAI PITINCA, MARIA DEA;FRANCOLINI, VALENTINA;Fui, Annalisa;BARGAGLI, ELENA;REFINI, ROSA METELLA;BENNETT, DAVID;NUTI, RANUCCIO;ROTTOLI, PAOLA
2016-01-01

Abstract

Idiopathic pulmonary fibrosis (IPF) is a rare form of chronic, progressive fibrosing interstitial pneumonia of unknown cause. The aim of this cross-sectional study was to assess the prevalence of osteoporosis and fragility fracture in a population of adults with IPF and to identify whether any possible clinical and pulmonary function parameters may be associated with increased bone fragility. In 58 IPF patients (mean age 65.1 ± 9.1 years), we measured bone mineral density (BMD) of the lumbar spine, the femoral neck, and the entire hip. Moreover, the presence of vertebral fractures on a lateral chest X-ray study was evaluated, and a vertebral fracture burden was quantified using the spinal deformity index (SDI). As expected, osteoporosis was significantly more frequent in females with respect to males (57.9 vs 20.5 %, respectively), whereas the fractures prevailed in males with respect to females (38.5 vs 26.3 %, respectively). There were positive correlations between BMD at all skeletal sites and respiratory parameters; in particular for FVC % and DLCO % with BMD at femoral sub-regions. Moreover, we compared the average of DLCO (%) measure by values of SDI score that was higher in those patients with lower values of DLCO (%). The study shows a high prevalence of fragility with vertebral fractures in IPF patients, especially in males. Moreover, the vertebral fracture burden is associated with a worsening of FVC (%) and DLCO (%). Therefore, an evaluation of bone status is recommended, especially in those patients who are candidates for lung transplantation.
Caffarelli, C., Gonnelli, S., TOMAI PITINCA, M.D., Francolini, V., Fui, A., Bargagli, E., et al. (2016). Idiopathic pulmonary fibrosis a rare disease with severe bone fragility. INTERNAL AND EMERGENCY MEDICINE, 11(8), 1087-1094 [10.1007/s11739-016-1501-z].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/996476