Major histocompatibility complex (HLA in humans) encodes membrane proteins which play a very important role in the activation of the immune system. Besides the well known class I molecules (HLA-A, B, C) and class II molecules (HLA-DR, DQ, DP), loci have been discovered whose products are involved in antigen processing and presentation, such as the 'peptide transporter genes' and the 'proteasomes'. In addition, MHC-encoded heat shock proteins may be involved in delivering peptides to class II molecules and to membrane transport proteins which pump peptides into the endoplasmic reticulum for coupling with class I molecules, and the regulatory promotor regions of HLA class II molecules influence the transcriptional levels of the structural genes. MHC is equivalent to an eukaryotic operon encoding a complete kit for the processing and presentation of antigens to T lymphocytes. This kit includes various sets of genes for molecules with distinct functions. Various degrees of polymorphism exist in all these classes of genes. These polymorphisms could contribute to the disease associations at present attributed to the MHC glycoproteins.
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|Titolo:||FUNZIONE DELLE MOLECOLE HLA DI CLASSE I E II: CORRELAZIONI CON L'AUTOIMMUNITA|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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