The homeostatic control of beta-cell mass in normal and pathological conditions is based on the balance of proliferation, differentiation, and death of the insulin-secreting cells. A considerable body of evidence, accumulated during the last decade, has emphasized the significance of the disregulation of the mechanisms regulating the apoptosis of beta-cells in the sequence of events that lead to the development of diabetes. The identification of agents capable of interfering with this process needs to be based on a better understanding of the beta-cell specific pathways that are activated during apoptosis. The aim of this article is fivefold: (1) a review of the evidence for beta-cell apoptosis in Type I diabetes, Type II diabetes, and islet transplantation, (2) to review the common stimuli and their mechanisms in pancreatic beta-cell apoptosis, (3) to review the role of caspases and their activation pathway in beta-cell apoptosis, (4) to review the caspase cascade and morphological cellular changes in apoptotic beta-cells, and (5) to highlight the putative strategies for preventing pancreatic beta-cells from apoptosis.

Hui, H., Dotta, F., Di Mario, U., Perfetti, R. (2004). Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. JOURNAL OF CELLULAR PHYSIOLOGY, 200(2), 177-200 [10.1002/jcp.20021].

Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death.

DOTTA, FRANCESCO;
2004-01-01

Abstract

The homeostatic control of beta-cell mass in normal and pathological conditions is based on the balance of proliferation, differentiation, and death of the insulin-secreting cells. A considerable body of evidence, accumulated during the last decade, has emphasized the significance of the disregulation of the mechanisms regulating the apoptosis of beta-cells in the sequence of events that lead to the development of diabetes. The identification of agents capable of interfering with this process needs to be based on a better understanding of the beta-cell specific pathways that are activated during apoptosis. The aim of this article is fivefold: (1) a review of the evidence for beta-cell apoptosis in Type I diabetes, Type II diabetes, and islet transplantation, (2) to review the common stimuli and their mechanisms in pancreatic beta-cell apoptosis, (3) to review the role of caspases and their activation pathway in beta-cell apoptosis, (4) to review the caspase cascade and morphological cellular changes in apoptotic beta-cells, and (5) to highlight the putative strategies for preventing pancreatic beta-cells from apoptosis.
2004
Hui, H., Dotta, F., Di Mario, U., Perfetti, R. (2004). Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. JOURNAL OF CELLULAR PHYSIOLOGY, 200(2), 177-200 [10.1002/jcp.20021].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/9951
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