Objective. To prospectively evaluate if computed tomography perfusion (CTp) could be a useful tool in addition to multiphasic CT in renal lesion characterisation. Materials and Methods. Fifty-eight patients that were scheduled for surgical resection of a renal mass with a suspicion of renal cell carcinoma (RCC) were enrolled. Forty-one out of 58 patients underwent total or partial nephrectomy after CTp examination, and a pathological analysis was obtained for a total of 49 renal lesions. Perfusion parameters and attenuation values at multiphasic CT for both lesion and normal cortex were analysed. All the results were compared with the histological data obtained following surgery. Results. PS and MTT values were significantly lower in malignant lesions than in the normal cortex (P < 0.001 and P = 0.011, resp.); PS, MTT, and BF values were also statistically different between oncocytomas and malignant lesions. According to ROC analysis, the accuracy, sensitivity, and specificity to predict RCC were 95.92%, 100%, and 66.7%, respectively, for CTp whereas they were 89.80%, 93.35%, and 50%, respectively, for multiphasic CT. Conclusion. A significant difference between renal cortex and tumour CTp parameter values may suggest a malignant renal lesion. CTp could represent an added value to multiphasic CT in differentiating renal cells carcinoma from oncocytoma.

Mazzei, F.G., Mazzei, M.A., CIOFFI SQUITIERI, N., Pozzessere, C., Righi, L., Cirigliano, A., et al. (2014). CT perfusion in the characterisation of renal lesions: An added value to multiphasic CT. BIOMED RESEARCH INTERNATIONAL, 2014(Article ID: 135013), 1-10 [10.1155/2014/135013].

CT perfusion in the characterisation of renal lesions: An added value to multiphasic CT

MAZZEI, MARIA ANTONIETTA;CIOFFI SQUITIERI, NEVADA;POZZESSERE, CHIARA;RIGHI, LORENZO;CIRIGLIANO, ALFREDO;GUERRINI, SUSANNA;D'ELIA, DOMENICO;AMBROSIO, MARIA RAFFAELLA;BARONE, AURORA;DEL VECCHIO, MARIA TERESA;VOLTERRANI, LUCA
2014-01-01

Abstract

Objective. To prospectively evaluate if computed tomography perfusion (CTp) could be a useful tool in addition to multiphasic CT in renal lesion characterisation. Materials and Methods. Fifty-eight patients that were scheduled for surgical resection of a renal mass with a suspicion of renal cell carcinoma (RCC) were enrolled. Forty-one out of 58 patients underwent total or partial nephrectomy after CTp examination, and a pathological analysis was obtained for a total of 49 renal lesions. Perfusion parameters and attenuation values at multiphasic CT for both lesion and normal cortex were analysed. All the results were compared with the histological data obtained following surgery. Results. PS and MTT values were significantly lower in malignant lesions than in the normal cortex (P < 0.001 and P = 0.011, resp.); PS, MTT, and BF values were also statistically different between oncocytomas and malignant lesions. According to ROC analysis, the accuracy, sensitivity, and specificity to predict RCC were 95.92%, 100%, and 66.7%, respectively, for CTp whereas they were 89.80%, 93.35%, and 50%, respectively, for multiphasic CT. Conclusion. A significant difference between renal cortex and tumour CTp parameter values may suggest a malignant renal lesion. CTp could represent an added value to multiphasic CT in differentiating renal cells carcinoma from oncocytoma.
Mazzei, F.G., Mazzei, M.A., CIOFFI SQUITIERI, N., Pozzessere, C., Righi, L., Cirigliano, A., et al. (2014). CT perfusion in the characterisation of renal lesions: An added value to multiphasic CT. BIOMED RESEARCH INTERNATIONAL, 2014(Article ID: 135013), 1-10 [10.1155/2014/135013].
File in questo prodotto:
File Dimensione Formato  
perf ren.pdf

accesso aperto

Tipologia: PDF editoriale
Licenza: Creative commons
Dimensione 3.51 MB
Formato Adobe PDF
3.51 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/984357
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo