Objective: To investigate changes in global metabolic profile between: 1-breast milk and formula milk, 2-breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age. Methods: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks. Results: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants 29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age. Conclusions: Metabolome is a promising tool to study human and artificial milk global metabolic profile.

Longini, M., Tataranno, M.L., Proietti, F., Tortoriello, M., Belvisi, E., Vivi, A., et al. (2014). A metabolomic study of preterm and term human and formula milk by proton MRS analysis: Preliminary results. THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 27(S2), 27-33 [10.3109/14767058.2014.955958].

A metabolomic study of preterm and term human and formula milk by proton MRS analysis: Preliminary results

Longini, Mariangela;Tataranno, Maria Luisa;Proietti, Fabrizio;Vivi, Antonio;Tassini, Maria;Buonocore, Giuseppe
2014-01-01

Abstract

Objective: To investigate changes in global metabolic profile between: 1-breast milk and formula milk, 2-breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age. Methods: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks. Results: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants 29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age. Conclusions: Metabolome is a promising tool to study human and artificial milk global metabolic profile.
Longini, M., Tataranno, M.L., Proietti, F., Tortoriello, M., Belvisi, E., Vivi, A., et al. (2014). A metabolomic study of preterm and term human and formula milk by proton MRS analysis: Preliminary results. THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 27(S2), 27-33 [10.3109/14767058.2014.955958].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/982636
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