Many previous studies have demonstrated that P2X7 receptors (P2X7Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X7R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biological features of P2X7R and summarize the current knowledge about the putative role of the P2X7R in triggering fibrosis in a wide spectrum of organs such as the lung, kidney, liver, pancreas, and heart.
Gentile, D., Natale, M., Lazzerini, P.E., Capecchi, P.L., LAGHI PASINI, F. (2015). The role of P2X7 receptors in tissue fibrosis: a brief review. PURINERGIC SIGNALLING, 11(4), 435-440 [10.1007/s11302-015-9466-3].
The role of P2X7 receptors in tissue fibrosis: a brief review
GENTILE, DANIELA;NATALE, MARIARITA;LAZZERINI, PIETRO ENEA;CAPECCHI, PIER LEOPOLDO;LAGHI PASINI, FRANCO
2015-01-01
Abstract
Many previous studies have demonstrated that P2X7 receptors (P2X7Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X7R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biological features of P2X7R and summarize the current knowledge about the putative role of the P2X7R in triggering fibrosis in a wide spectrum of organs such as the lung, kidney, liver, pancreas, and heart.
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https://hdl.handle.net/11365/982600
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