After 14 years since the last edition, the Study Group on Autoimmune Diseases (GdS-AI) of the Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL) has revised and supplemented the “Guidelines for the laboratory use of autoantibody tests in the diagnosis and monitoring of autoimmune rheumatic diseases”, with addition of new themes, update of recommendations and revaluation of the controversial aspects of the previous document. For the preparation of this edition, the assessment of the “quality of evidence” and of “strength of the recommendations”has been defined by the GRADE (Grading of Recommendation Assessment, Development and Evaluation) method, developed in 2000 by an international working group as a rigorous and explicit method for the production of clinical recommendations. The document is divided into 4 sections including 18 recommendations; each is introduced by a question, followed by the systematic evaluation of the scientific literature and the quality of the evidence found. The formal definition of the strength of the recommendations, expressed as “strong” or “weak”, has been assigned by consensus of all members of GdS-AI SIPMeL. This updated revision of the guidelines provides an overview on thecurrent status of the tests for the detection of autoantibodies to intracellular antigens, including solid phase immunoassays and the automated reading of indirect immunofluorescence. Recommendations are directed mainly to the appropriateness of the request, the analytical methodology to be used, the interpretation and reporting of results. Finally, the document approaches open issues, such as the use of new terms and acronyms to name autoantibody tests used to diagnose autoimmune rheumatic diseases and the harmonization of procedures for the detection of autoantibodies.

Linee guida per l’utilizzo dei test autoanticorpali nella diagnosi e nel monitoraggio delle malattie autoimmuni reumatiche sistemiche. Revisione 2015. Guidelines for the laboratory use of autoantibody tests in the diagnosis and monitoring of autoimmune rheumatic diseases. Revision 2015

MOROZZI, GABRIELLA;PORCELLI, BRUNETTA;TERZUOLI, LUCIA;
2015

Abstract

After 14 years since the last edition, the Study Group on Autoimmune Diseases (GdS-AI) of the Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL) has revised and supplemented the “Guidelines for the laboratory use of autoantibody tests in the diagnosis and monitoring of autoimmune rheumatic diseases”, with addition of new themes, update of recommendations and revaluation of the controversial aspects of the previous document. For the preparation of this edition, the assessment of the “quality of evidence” and of “strength of the recommendations”has been defined by the GRADE (Grading of Recommendation Assessment, Development and Evaluation) method, developed in 2000 by an international working group as a rigorous and explicit method for the production of clinical recommendations. The document is divided into 4 sections including 18 recommendations; each is introduced by a question, followed by the systematic evaluation of the scientific literature and the quality of the evidence found. The formal definition of the strength of the recommendations, expressed as “strong” or “weak”, has been assigned by consensus of all members of GdS-AI SIPMeL. This updated revision of the guidelines provides an overview on thecurrent status of the tests for the detection of autoantibodies to intracellular antigens, including solid phase immunoassays and the automated reading of indirect immunofluorescence. Recommendations are directed mainly to the appropriateness of the request, the analytical methodology to be used, the interpretation and reporting of results. Finally, the document approaches open issues, such as the use of new terms and acronyms to name autoantibody tests used to diagnose autoimmune rheumatic diseases and the harmonization of procedures for the detection of autoantibodies.
File in questo prodotto:
File Dimensione Formato  
Lavoro Porcelli 297.pdf

non disponibili

Tipologia: PDF editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.08 MB
Formato Adobe PDF
1.08 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/982392
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo