In a possible scenario for the origin of life there was a time in which informational genetic polymers played primary roles. Transfer-RNA molecules may be considered possible “fossils” of that primitive era (billions years ago). In order to test the hypothesis that the nucleotide sequences of the primitive informational polymers might not be chosen randomly, we propose a comparison of computer-generated random sequences with tRNAs nucleotide sequences present in anaerobic Archaea. Nucleotide sequence data of archaeal tRNA genes were obtained from the Institute for Genomic Research (TIGR) and the GeneBank library. Random sequence data (white noise) were obtained from the algorithm by Press and Teukolsky. Relative Lempel-Ziv complexity and Entropy of nucleotide sequences and of computer generated random represented as random walks were evaluated. Manhattan and Euclidean "fractal" dimensions of nucleotide sequences (DM, DE) were also evaluated. Nonlinear parameters obtained from the Archaea are lower than the values of randomly generated sequences (p<0.01, p<0.01). DM and DE confirm the results (p<0.01, p<0.01). The observed deviation from pure randomness should be arisen from some constraints like the secondary structure of this biologic macromolecule and/or from a “frozen” stochastic transition when informational polymers originated. The nonlinear evaluation of nucleotide sequences expressed as random walks, here presented, provides an efficient assessment of the primary structure of nucleic acid sequences.
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|Titolo:||Informational polymers in the primitive Earth: Lempel-Ziv complexity and Entropy of tRNAs in anaerobic Archaea compared to computer-generated random data.|
|Citazione:||Bianciardi, G. (2015). Informational polymers in the primitive Earth: Lempel-Ziv complexity and Entropy of tRNAs in anaerobic Archaea compared to computer-generated random data. RESEARCH & REVIEWS IN BIOSCIENCES, 10(6), 231-234.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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