An efficient one-pot ruthenium-catalyzed hydrogen-transfer strategy for a direct access to α,β-unsaturated aldehydes has been developed. The employment of enolates prepared in situ from alcohols avoided handling unstable aldehydes and provided a very appealing route to different cinnamaldehydes substituted in position 2. A silica-grafted amine was used as phase-switch tag leading to a selective one-pot process in favor of cross-dehydrogenative coupling products.
|Titolo:||Synthesis of α,β-unsaturated aldehydes based on a one-pot phase-switch dehydrogenative cross-coupling of primary alcohols|
|Citazione:||Mura, M.G., De Luca, L., Taddei, M., Williams, J.M.J., & Porcheddu, A. (2014). Synthesis of α,β-unsaturated aldehydes based on a one-pot phase-switch dehydrogenative cross-coupling of primary alcohols. ORGANIC LETTERS, 16(10), 2586-2589.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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