Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.
Bartha, I., Assel, M., Sloot, P.M.A., Zazzi, M., Torti, C., Schülter, E., et al. (2013). Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort. BMC INFECTIOUS DISEASES, 13(1) [10.1186/1471-2334-13-537].
Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort
ZAZZI, MAURIZIO;De Luca, Andrea;ROSI, ANDREA;
2013-01-01
Abstract
Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/974447
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