A total of 81 HIV-1 protease (PR) and reverse transcriptase (RT) sequences were obtained from 46 drug-naive and 35 pretreated individual HIV-1-infected orphaned children followed at a donor-funded rural pediatric clinic in Dodoma, Tanzania. PR and RT sequencing was performed by home-brew technology on 70 plasma samples and 11 dried blood spot specimens. Nucleoside RT inhibitor (NRTI) resistance mutations were detected in 2.2% of drug-naive and 82.9% of pretreated children. Nonnucleoside RT inhibitor (NNRTI) resistance mutations were detected in 69.6% of drug-naive and 91.4% of pretreated children. Resistance to protease inhibitors was rare (8.6% in pretreated children). Based on few complete treatment records, only around 20% of the treated children had undetectable plasma HIV-1 RNA. The rate of NRTI and NNRTI resistance in this donor-funded rural pediatric clinic was high and appeared to limit virological response to treatment.
|Titolo:||Frequent Detection of Antiretroviral Drug Resistance in HIV-1-Infected Orphaned Children Followed at a Donor-Funded Rural Pediatric Clinic in Dodoma, Tanzania|
|Citazione:||Frequent Detection of Antiretroviral Drug Resistance in HIV-1-Infected Orphaned Children Followed at a Donor-Funded Rural Pediatric Clinic in Dodoma, Tanzania / Meini, Genny; Balestrieri, Maddalena; Cianchino, Sergio; Tacconi, Danilo; Rossi de Gasperis, Marco; Concato, Carlo; Vicenti, Ilaria; Rosi, Andrea; Saladini, Francesco; Callea, Francesco; Zazzi, Maurizio. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - STAMPA. - 31(2015), pp. 448-451.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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