Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide eﬄux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3 is 52,491 bp in length and contained 58 open reading frames (ORFs). A manual homology-based annotation with functional prediction of the hypothetical gene product was possible only for 34 out of 58 ORFs. Φ1207.3 codes for two different C-methylation systems, several phage structural genes, a lysis cassette (composed by a holin and a peptidoglycan hydrolase), and three site-specific resolvases of the serine recombinase family.
|Titolo:||Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for eﬄux resistance to macrolides in Streptococcus pyogenes|
|Citazione:||Iannelli, F., Santagati, M., Santoro, F., Oggioni, M.R., Stefani, S., & Pozzi, G. (2014). Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for eﬄux resistance to macrolides in Streptococcus pyogenes. FRONTIERS IN MICROBIOLOGY, 5, 1-7.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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