Purpose: To describe the characteristics of vacuolating Helicobacter pylori cytotoxin and its importance in gastroduodenal pathology. Method: Survey of recent studies. Conclusion: Certain H. pylori strains produce a unique toxin, a protein with a molecular weight of about 87 000, which induces vacuole formation in mammalian cells in vitro, and may also have harmful effects in vivo on gastric epithelial cells. Immune recognition by dyspeptic patients of a cytotoxin-associated protein with a molecular weight of 128 000 is associated with more serious gastroduodenal pathologies, ranging from severe gastritis to atrophy and, probably, gastric cancer.
Figura, N. (1993). Role of cytotoxin in the pathogenesis of Helicobacter pylori infection. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 5(Supplemento 2), 16-18.
Role of cytotoxin in the pathogenesis of Helicobacter pylori infection
FIGURA, NATALE
1993-01-01
Abstract
Purpose: To describe the characteristics of vacuolating Helicobacter pylori cytotoxin and its importance in gastroduodenal pathology. Method: Survey of recent studies. Conclusion: Certain H. pylori strains produce a unique toxin, a protein with a molecular weight of about 87 000, which induces vacuole formation in mammalian cells in vitro, and may also have harmful effects in vivo on gastric epithelial cells. Immune recognition by dyspeptic patients of a cytotoxin-associated protein with a molecular weight of 128 000 is associated with more serious gastroduodenal pathologies, ranging from severe gastritis to atrophy and, probably, gastric cancer.
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https://hdl.handle.net/11365/9553
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