An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a -ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal−Knorr procedure carried out under microwave irradiation.
G., M., Taddei, M. (2004). Microwave assisted Paal-Knorr reaction. A rapid approach to polysubstituted furans and pyrroles. ORGANIC LETTERS, 6, 389-392.
Microwave assisted Paal-Knorr reaction. A rapid approach to polysubstituted furans and pyrroles
TADDEI, MAURIZIO
2004-01-01
Abstract
An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a -ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal−Knorr procedure carried out under microwave irradiation.
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