An efficient synthesis of tetrahydroindoles with different substituents in position I is described. Microwave-assisted aminolysis of 4-oxo-4,5,6,7-tetrahydrobenzofuran With different primary amines gives the corresponding tetrahydroindoles in few minutes. All attempts to use microwave dielectric heating to reduce the time required for preparation of 4-oxo-4,5,6,7-tetrahydrobenzofuran, starting from 1,3-cyclohexandione were on the other hand unsuccessful, demonstrating that in some cases, long time conventional heating may be superior to microwaves. (C) 2007 Elsevier Ltd. All rights reserved.
Piras, L., Ghiron, C., Minetto, G., Taddei, M. (2008). Microwave-assisted synthesis of tetrahydroindoles. TETRAHEDRON LETTERS, 49(3), 459-462 [10.1016/j.tetlet.2007.11.114].
Microwave-assisted synthesis of tetrahydroindoles
Piras, Leonarda;Minetto, Giacomo;Taddei, Maurizio
2008-01-01
Abstract
An efficient synthesis of tetrahydroindoles with different substituents in position I is described. Microwave-assisted aminolysis of 4-oxo-4,5,6,7-tetrahydrobenzofuran With different primary amines gives the corresponding tetrahydroindoles in few minutes. All attempts to use microwave dielectric heating to reduce the time required for preparation of 4-oxo-4,5,6,7-tetrahydrobenzofuran, starting from 1,3-cyclohexandione were on the other hand unsuccessful, demonstrating that in some cases, long time conventional heating may be superior to microwaves. (C) 2007 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/9244
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