A new family of pyrrole-based amino acids have been prepared through the microwave assisted Paal-Knorr reaction of 1-4 ketoesters derived from the corresponding β-ketoester with a functional homologation. The carboxylic group is located in position 3 of the pyrrole, whereas the amino group, protected with the Cbz moiety, is present on the side chain in positions 1 or 2. These compounds were used to prepare constrained oligopeptides. © 2005 Elsevier Ltd. All rights reserved.
Alongi, M., Minetto, G., Taddei, M. (2005). New Pyrrole-based amino acids for the synthesis of peptidomimetic constrained scaffolds. TETRAHEDRON LETTERS, 46(41), 7069-7072 [10.1016/j.tetlet.2005.07.155].
New Pyrrole-based amino acids for the synthesis of peptidomimetic constrained scaffolds
Minetto, Giacomo;Taddei, Maurizio
2005-01-01
Abstract
A new family of pyrrole-based amino acids have been prepared through the microwave assisted Paal-Knorr reaction of 1-4 ketoesters derived from the corresponding β-ketoester with a functional homologation. The carboxylic group is located in position 3 of the pyrrole, whereas the amino group, protected with the Cbz moiety, is present on the side chain in positions 1 or 2. These compounds were used to prepare constrained oligopeptides. © 2005 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/9234
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